Quality of life issues in patients with bone metastases: A systematic review.

Autor: Rajeswaran T; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada., Wong HCY; Department of Oncology, Princess Margaret Hospital, Hospital Authority, Kowloon, Hong Kong., Zhang E; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada., Kennedy SKF; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada., Gojsevic M; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada., Soliman H; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada., Vassiliou V; Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus., Rades D; Department of Radiation Oncology, University of Lübeck, Lübeck, Germany., Bonomo P; Department of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Lee SF; Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore.; Department of Clinical Oncology, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, New Territories, Hong Kong., Chan AW; Department of Clinical Oncology, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, New Territories, Hong Kong., Rembielak A; The University of Manchester, Manchester, UK.; Department of Clinical Oncology, The Christie HNS Foundation Trust, Manchester, UK., Oldenburger E; Department of Radiation Oncology, University Hospitals Leuven, Louvain, Belgium., Maranzano E; Radiotherapy Oncology Centre, Santa Maria Hospital, Terni, Italy.; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Pergolizzi S; Radiation Oncology Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Italy., Finkelstein JA; Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Larouche J; Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Zhang N; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China., Zhang X; Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China., Marta GN; Department of Radiation Oncology, Hospital Sírio-Libanês, Sao Paulo, Brazil., Yee AJM; Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Yu S; Department of Orthopedics, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., van der Velden JM; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., van der Linden YM; Department of Radiotherapy, Leiden University Medical Center, University of Leiden, Leiden, Holland., Chow E; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada. edward.chow@sunnybrook.ca.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Dec 13; Vol. 32 (1), pp. 18. Date of Electronic Publication: 2023 Dec 13.
DOI: 10.1007/s00520-023-08241-0
Abstrakt: Introduction: Bones are frequent sites of metastatic disease, observed in 30-75% of advanced cancer patients. Quality of life (QoL) is an important endpoint in studies evaluating the treatments of bone metastases (BM), and many patient-reported outcome tools are available. The primary objective of this systematic review was to compile a list of QoL issues relevant to BM and its interventions. The secondary objective was to identify common tools used to assess QoL in patients with BM, and the QoL issues they fail to address.
Methods: A search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases between 1946 and 27 January 2023 with the keywords "bone metastases", "quality of life", and "patient reported outcomes". Specific QoL issues in original research studies and the QoL tools used were extracted.
Results: The review identified the QoL issues most prevalent to BM in the literature. Physical and functional issues observed in patients included pain, interference with ambulation and daily activities, and fatigue. Psychological symptoms, such as helplessness, depression, and anxiety were also common. These issues interfered with patients' relationships and social activities. Items not mentioned in existing QoL tools were related to newer treatments of BM, such as pain flare, flu-like symptoms, and jaw pain due to osteonecrosis.
Conclusions: This systematic review highlights that QoL issues for patients with BM have expanded over time due to advances in BM-directed treatments. If they are relevant, additional treatment-related QoL issues identified need to be validated prospectively by patients and added to current assessment tools.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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