Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria.

Autor: Happi AN; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ogunsanya OA; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ayinla AO; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Sijuwola AE; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Saibu FM; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Akano K; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.; Redeemer's University, Ede, Osun, Nigeria., Nwofoke C; Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Elias OT; University of Nigeria, Nsukka, Nigeria., Achonduh-Atijegbe O; Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria., Daodu RO; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Adedokun OA; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Adeyemo A; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Ogundana KE; Redeemer's University, Ede, Osun, Nigeria., Lawal OZ; Redeemer's University, Ede, Osun, Nigeria., Parker E; Scripps Translational Science Institute, La Jolla, CA, USA., Nosamiefan I; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Okolie J; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria., Parker ZF; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., McCauley MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Eller LA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Lombardi K; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Tiamiyu AB; Henry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, Nigeria.; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Iroezindu M; Henry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, Nigeria.; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Akinwale E; Henry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, Nigeria.; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Njatou TLFA; One Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Mebrahtu T; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Broach E; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Zuppe A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Prins P; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Lay J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Amare M; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Modjarrad K; Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Collins ND; Viral Diseases Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Vasan S; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Tucker C; One Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Daye S; One Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA., Happi CT; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.; Redeemer's University, Ede, Osun, Nigeria.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Emerging microbes & infections [Emerg Microbes Infect] 2024 Dec; Vol. 13 (1), pp. 2294859. Date of Electronic Publication: 2024 Jan 22.
DOI: 10.1080/22221751.2023.2294859
Abstrakt: Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from 2021-2022 in four locations in southern Nigeria with reported cases of Lassa fever (LF). Birds, lizards, and domestic mammals (dogs, pigs, cattle and goats) were screened using RT-qPCR, and whole genome sequencing was performed for lineage identification on selected LASV positive samples. Animals were also screened for exposure to LASV by enzyme-linked immunosorbent assay (ELISA). Among these animals, lizards had the highest positivity rate by PCR. Genomic sequencing of samples in most infected animals showed sub-lineage 2 g of LASV. Seropositivity was highest among cattle and lowest in pigs. Though the specific impact these additional hosts may have in the broader virus-host context are still unknown - specifically relating to pathogen diversity, evolution, and transmission - the detection of LASV in non-rodent hosts living in proximity to confirmed human LF cases suggests their involvement during transmission as potential reservoirs. Additional epidemiological data comparing viral genomes from humans and animals, as well as those circulating within the environment will be critical in understanding LASV transmission dynamics and will ultimately guide the development of countermeasures for this zoonotic health threat.
Databáze: MEDLINE