Association of clinical symptoms and cardiometabolic dysregulations in patients with schizophrenia spectrum disorders.
Autor: | Zhao C; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Habtewold TD; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Naderi E; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Liemburg EJ; Department of Psychiatry, Rob Giel Research Center, University Center for Psychiatry, Groningen, The Netherlands., Bruggeman R; Department of Psychiatry, Rob Giel Research Center, University Center for Psychiatry, Groningen, The Netherlands., Alizadeh BZ; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
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Jazyk: | angličtina |
Zdroj: | European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2023 Dec 13; Vol. 67 (1), pp. e7. Date of Electronic Publication: 2023 Dec 13. |
DOI: | 10.1192/j.eurpsy.2023.2477 |
Abstrakt: | Background: Patients with schizophrenia spectrum disorders (SSD) have a shortened life expectancy related to cardiovascular diseases. We investigated the association of cognitive, positive, and negative symptoms with cardiometabolic dysregulations in SSD patients. Methods: Overall, 1,119 patients from the Genetic Risk and Outcome in Psychosis (GROUP) study were included. Cognitive function, positive and negative symptoms were assessed at baseline, 3-year, and 6-year. Cardiometabolic biomarkers were measured at 3-year follow-up. We used linear and multinomial logistic regression models to test the association between cardiometabolic biomarkers and clinical trajectories and performed mediation analyzes, while adjusting for clinical and demographic confounders. Results: Cognitive performance was inversely associated with increased body mass index (mean difference [β], β Conclusions: We showed an association between cardiometabolic dysregulations and clinical and cognitive symptoms in SSD patients. The observed associations underscore the need for early identification of patients at risk of cardiometabolic outcomes. |
Databáze: | MEDLINE |
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