Prehabilitative high-intensity interval training and resistance exercise in patients prior allogeneic stem cell transplantation.

Autor: Kuehl R; Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany., Feyer J; Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany., Limbach M; Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany., Pahl A; Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center -University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Stoelzel F; Prevention Center of the National Center for Tumor Diseases Dresden (NCT/UCC), Dresden, Germany., Beck H; Department of Sports Medicine, University Center for Orthopedics, Trauma and Plastic Surgery, Dresden, Germany., Wegner A; Medical Clinic II, Hematology-Oncology, University Clinic Frankfurt, University Cancer Center (UCT) Frankfurt, Frankfurt, Germany., Rosenberger F; Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.; Division of Health Sciences, German University of Applied Sciences for Prevention and Health Management, Saarbrucken, Germany., Dreger P; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Luft T; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Wiskemann J; Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. joachim.wiskemann@nct-heidelberg.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Dec 12; Vol. 13 (1), pp. 22069. Date of Electronic Publication: 2023 Dec 12.
DOI: 10.1038/s41598-023-49420-7
Abstrakt: Physical capacity prior allogeneic stem cell transplantation (allo-HCT) has been shown as a relevant prognostic factor for survival after transplant. Therefore, we evaluated feasibility and preliminary efficacy of a high-intensity interval training (HIIT) and moderate to high-intensity resistance exercise (RE) to increase physical capacity in patient's prior allo-HCT. In this multicentre single arm pilot study, a supervised exercise program was performed twice weekly for 4-12 weeks prior allo-HCT, depending on the individual time remaining. Outcomes were feasibility (recruitment, adherence, safety), physical capacity (cardiorespiratory fitness [VO2peak], muscle strength) and patient reported outcomes (physical functioning, fatigue). Thirty patients were intended, 16 could be included, and 14 completed post intervention assessment (75% male, 55 ± 11 years). The study was stopped early due to a low recruitment rate. Nine patients (64%) reached the initial minimum planned number of eight exercise sessions. Individual adherence was high with 92% for HIIT and 85% for RE. 87% of all performed exercise sessions were completed without complaints and VO2peak increased significantly from 20.4 to 23.4 ml/kg/min. The low recruitment rate suggests that initiation of the intervention concept immediately before allo-HCT is feasible only in a small number of patients. In particular, the timeframe directly prior allo-HCT seems too short for exercise interventions, although the exercise program was designed to improve outcomes in a very short time frame. HIIT and RE were feasible, effective and well accepted by the included patients.
(© 2023. The Author(s).)
Databáze: MEDLINE
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