| Autor: |
Dissanayaka DDS; Department of Zoology, Faculty of Science, University of Ruhuna, Matara, Sri Lanka., Gunawickrama SHNP; Institute for Combinatorial Advanced Research and Education, General Sir John Kotelawala Defence University, Ratmalana, Sri Lanka., Dharmapriya TN; Institute of Environmental Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan., Gunawickrama KBS; Department of Zoology, Faculty of Science, University of Ruhuna, Matara, Sri Lanka. |
| Jazyk: |
angličtina |
| Zdroj: |
Drug and chemical toxicology [Drug Chem Toxicol] 2024 Nov; Vol. 47 (6), pp. 817-826. Date of Electronic Publication: 2023 Dec 12. |
| DOI: |
10.1080/01480545.2023.2291983 |
| Abstrakt: |
The occurrence of pharmaceuticals in the environment can have undesirable effects on nontarget animals, including fish. The present experiment assessed the effects of subchronic exposure to waterborne acetaminophen (N-acetyl-p-aminophenol) (APAP) on selected behavioral aspects (physical avoidance response, ventilation rate, and food detection rate) and erythrocyte nuclear abnormality (ENA) in juvenile Oreochromis niloticus . Two groups of fish were exposed to APAP dissolved in aged municipal water (T 1 : 2 mg/L and T 2 : 10 mg/L) for 8 weeks in three replicates ( n = 7 fish per tank), alongside a control group (C) without APAP. APAP-exposed fish spent significantly ( p < .05) longer time to detect food (T 1 : 32.6 ± 4.55 s and T 2 : 39.6 ± 4.66 s) compared to the control group (19.9 ± 2.46 s). Both APAP-exposed groups exhibited attenuated physical avoidance responses (76.7%, 68.7%, and 87.3% in T 1 , T 2 , and C, respectively) and a lower mean ventilation rate compared to the control group (194.5 ± 15.5, 179.1 ± 11.6, and 233.2 ± 19.0 per min in T 1 , T 2 , and C, respectively). The frequency occurrence of ENA types such as bi-nucleated, notched nuclei, lobed nuclei, and blebbed nuclei (except micronuclei) was significantly higher ( p < .05) in APAP-exposed groups compared to the control, with more pronounced effects in the T 2 group. The study concludes that APAP exposure prompts significant alterations in behavior and erythrocyte nuclear morphology, emphasizing the value of monitoring and regulating the entry of pharmaceuticals, including APAP, into aquatic environments to prevent unintended effects on non-target organisms like Oreochromis niloticus . |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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