Estimation of Renal Clearance in Hypertensive Rats According to fMRI Data.

Autor: Agafonova IG; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Division of the Russian Academy of Sciences, Vladivostok, Russia. agafonova@piboc.dvo.ru., Kotelnikov VN; Far Eastern Branch of the State Research Test Institute of Military Medicine, Ministry of Defense of the Russian Federation, Vladivostok, Russia.; Far Eastern Federal University, Vladivostok, Russia., Geltser BI; Far Eastern Federal University, Vladivostok, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Nov; Vol. 176 (1), pp. 14-18. Date of Electronic Publication: 2023 Dec 12.
DOI: 10.1007/s10517-023-05958-0
Abstrakt: Renal clearance in Wistar rats with multifactorial cardiovasorenal model of arterial hypertension was assessed by fMRI using (EPI_Diffusion_map) protocol after injection of extracellular contrast agent gadolinium Gd-DTPA. Linear regression analysis was used to assess local concentrations of the contrast agent in the abdominal aorta, kidney compartments, pelvis, and bladder areas. Detection of marker clearance in order to verify the glomerular filtration rate was performed by the RPP (Rutland-Patlak plot) method. In 3 months after hypertension modeling, glomerular filtration rate decreased by 2 times in comparison with the control (31.2±0.44 and 62.3±1.31 μl/min/100 g, respectively; p<0.001). Our findings can indicate the formation of hypertensive nephroangiosclerosis in rats with experimental arterial hypertension. It was found that kidney damage in hypertensive rats is associated with hypofiltration.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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