Targeting Nanomotor with Near-Infrared/Ultrasound Triggered-Transformation for Polystage-Propelled Cascade Thrombolysis and Multimodal Imaging Diagnosis.

Autor: Ruan R; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, P. R. China.; Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, P. R. China., Chen S; Department of Ultrasound, Shengli Clinical Medical College of Fujian Medical University, 134 Dongjie Road, Fuzhou, 350001, P. R. China., Su J; Department of Anesthesiology, Fujian Nan'an Hospital, 330 Xinhua Street, Quanzhou, 362300, P. R. China., Liu N; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, P. R. China.; Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, P. R. China., Feng H; MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photo-catalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. China., Xiao P; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, P. R. China.; Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, P. R. China., Zhang X; MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photo-catalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. China., Pan G; MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photo-catalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. China., Hou L; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, P. R. China.; Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, P. R. China., Zhang J; College of Chemical Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350108, P. R. China.; Qingyuan Innovation Laboratory, 1 Xueyuan Road, Quanzhou, 362801, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Feb; Vol. 13 (5), pp. e2302591. Date of Electronic Publication: 2023 Dec 12.
DOI: 10.1002/adhm.202302591
Abstrakt: Nowadays, cardiovascular and cerebrovascular diseases caused by venous thromboembolism become main causes of mortality around the world. The current thrombolytic strategies in clinics are confined primarily due to poor penetration of nanoplatforms, limited thrombolytic efficiency, and extremely-low imaging accuracy. Herein, a novel nanomotor (NM) is engineered by combining iron oxide/perfluorohexane (PFH)/urokinase (UK) into liposome nanovesicle, which exhibits near-infrared/ultrasound (NIR/US) triggered transformation, achieves non-invasive vein thrombolysis, and realizes multimodal imaging diagnosis altogether. Interestingly, a three-step propelled cascade thrombolytic therapy is revealed from such intelligent NM. First, the NM is effectively herded at the thrombus site under guidance of a magnetic field. Afterwards, stimulations of NIR/US propel phase transition of PFH, which intensifies penetration of the NM toward deep thrombus dependent on cavitation effect. Ultimately, UK is released from the collapsed NM and achieves pharmaceutical thrombolysis in a synergistic way. After an intravenous injection of NM in vivo, the whole thrombolytic process is monitored in real-time through multimodal photoacoustic, ultrasonic, and color Doppler ultrasonic imagings. Overall, such advanced nanoplatform provides a brand-new strategy for time-critical vein thrombolytic therapy through efficient thrombolysis and multimodal imaging diagnosis.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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