APOL1 Risk Variants Associate With the Prevalence of Stroke in African American Current and Past Smokers.

Autor: Rakic JM; Cardiovascular Research Institute University of California, San Francisco CA USA.; Center for Tobacco Control Research and Education University of California, San Francisco CA USA., Pullinger CR; Cardiovascular Research Institute University of California, San Francisco CA USA.; Department of Physiological Nursing University of California, San Francisco CA USA., Van Blarigan EL; Department of Epidemiology and Biostatistics University of California, San Francisco CA USA., Movsesyan I; Cardiovascular Research Institute University of California, San Francisco CA USA., Stock EO; Cardiovascular Research Institute University of California, San Francisco CA USA.; Department of Medicine University of California, San Francisco CA USA., Malloy MJ; Cardiovascular Research Institute University of California, San Francisco CA USA.; Department of Medicine University of California, San Francisco CA USA., Kane JP; Cardiovascular Research Institute University of California, San Francisco CA USA.; Department of Medicine University of California, San Francisco CA USA.; Department of Biochemistry and Biophysics University of California, San Francisco CA USA.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2023 Dec 19; Vol. 12 (24), pp. e030796. Date of Electronic Publication: 2023 Dec 12.
DOI: 10.1161/JAHA.123.030796
Abstrakt: Background: African American smokers have 2.5 times higher risk for stroke compared with nonsmokers (higher than other races). About 50% of the African American population carry 1 or 2 genetic variants (G1 and G2; rare in other races) of the apolipoprotein L1 gene ( APOL1 ). Studies showed these variants may be associated with stroke. However, the role of the APOL1 risk variants in tobacco-related stroke is unknown.
Methods and Results: In a cross-sectional study, we examined whether APOL1 risk variants modified the relationship between tobacco smoking and stroke prevalence in 513 African American adults recruited at University of California, San Francisco. Using DNA, plasma, and questionnaires we determined APOL1 variants, smoking status, and stroke prevalence. Using logistic regression models, we examined the association between smoking ( ever versus never smokers) and stroke overall, and among carriers of APOL1 risk variants (1 or 2 risk alleles), and noncarriers, separately. Among participants, 41% were ever ( current and past ) smokers, 54% were carriers of the APOL1 risk variants, and 41 had a history of stroke. The association between smoking and stroke differed by APOL1 genotype ( P interaction term =0.014). Among carriers, ever versus never smokers had odds ratio (OR) 2.46 (95% CI, 1.08-5.59) for stroke ( P =0.034); OR 2.00 (95% CI, 0.81-4.96) among carriers of 1 risk allele, and OR 4.72 (95% CI, 0.62-36.02) for 2 risk alleles. Among noncarriers, smoking was not associated with a stroke.
Conclusions: Current and past smokers who carry APOL1 G1 and/or G2 risk variants may be more susceptible to stroke among the African American population.
Databáze: MEDLINE
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