Adrenoceptors in the Eye - Physiological and Pathophysiological Relevance.

Autor: Ruan Y; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Buonfiglio F; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Gericke A; Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany. adrian.gericke@unimedizin-mainz.de.
Jazyk: angličtina
Zdroj: Handbook of experimental pharmacology [Handb Exp Pharmacol] 2024; Vol. 285, pp. 453-505.
DOI: 10.1007/164_2023_702
Abstrakt: The autonomic nervous system plays a crucial role in the innervation of the eye. Consequently, it comes as no surprise that catecholamines and their corresponding receptors have been extensively studied and characterized in numerous ocular structures, including the cornea, conjunctiva, lacrimal gland, trabecular meshwork, uvea, and retina. These investigations have unveiled substantial clinical implications, particularly in the context of treating glaucoma, a progressive neurodegenerative disorder responsible for irreversible vision loss on a global scale. The primary therapeutic approaches for glaucoma frequently involve the modulation of α 1 -, α 2 -, and β-adrenoceptors, making them pivotal targets. In this chapter, we offer a comprehensive overview of the expression, distribution, and functional roles of adrenoceptors within various components of the eye and its associated structures. Additionally, we delve into the pivotal role of adrenoceptors in the pathophysiology of glaucoma. Furthermore, we provide a concise historical perspective on adrenoceptor research, examine the distinct contributions of individual adrenoceptor subtypes to the treatment of various ocular conditions, and propose potential future avenues of exploration in this field.
(© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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