Dopamine precursor depletion affects performance and confidence judgements when events are timed from an explicit, but not an implicit onset.

Autor: Jovanovic L; Inserm 1114, Centre for Psychiatry, University Hospital of Strasbourg, Strasbourg University, Strasbourg, France. lj.m.jovanovic@gmail.com.; Laboratoire des Systèmes Perceptifs, École Normale Supérieure, PSL University & CNRS, Paris, France. lj.m.jovanovic@gmail.com., Chassignolle M; Laboratoire des Neurosciences Cognitives (LNC), Aix-Marseille University & CNRS, Marseille, France., Schmidt-Mutter C; CIC Inserm 1434, CHU Strasbourg, Strasbourg, France., Behr G; Inserm 1114, Centre for Psychiatry, University Hospital of Strasbourg, Strasbourg University, Strasbourg, France., Coull JT; Laboratoire des Neurosciences Cognitives (LNC), Aix-Marseille University & CNRS, Marseille, France., Giersch A; Inserm 1114, Centre for Psychiatry, University Hospital of Strasbourg, Strasbourg University, Strasbourg, France. giersch@unistra.fr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Dec 11; Vol. 13 (1), pp. 21933. Date of Electronic Publication: 2023 Dec 11.
DOI: 10.1038/s41598-023-47843-w
Abstrakt: Dopamine affects processing of temporal information, but most previous work has tested its role in prospective tasks, where participants know in advance when the event to be timed starts. However, we are often exposed to events whose onset we do not know in advance. We can evaluate their duration after they have elapsed, but mechanisms underlying this ability are still elusive. Here we contrasted effects of acute phenylalanine and tyrosine depletion (APTD) on both forms of timing in healthy volunteers, in a within-subject, placebo-controlled design. Participants were presented with a disc moving around a circular path and asked to reproduce the duration of one full revolution and to judge their confidence in performance. The onset of the revolution was either known in advance (explicit onset) or revealed only at the end of the trial (implicit onset). We found that APTD shortened reproduced durations in the explicit onset task but had no effect on temporal performance in the implicit onset task. This dissociation is corroborated by effects of APTD on confidence judgements in the explicit task only. Our findings suggest that dopamine has a specific role in prospective encoding of temporal intervals, rather than the processing of temporal information in general.
(© 2023. The Author(s).)
Databáze: MEDLINE
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