Comparison of post-hepatectomy long-term survival outcome between non-colorectal non-neuroendocrine and colorectal liver metastases: A population-based propensity-score matching analysis.

Autor: Ng KKC; Department of Surgery, The Chinese University of Hong Kong, Hong Kong; Department of Surgery, Prince of Wales Hospital, New Territories, Hong Kong. Electronic address: kkcng95@gmail.com., Lok HT; Department of Surgery, Prince of Wales Hospital, New Territories, Hong Kong., Lee KF; Department of Surgery, Prince of Wales Hospital, New Territories, Hong Kong., Cheung TT; Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong., Chia NH; Department of Surgery, Queen Elizabeth Hospital, Hong Kong., Ng WK; Department of Surgery, Princes Margaret Hospital, Hong Kong., Law CK; Department of Surgery, Tuen Mun Hospital, Hong Kong., Cheung CY; Department of Surgery, Caritas Medical Centre, Hong Kong., Cheng KC; Department of Surgery, Kwong Wah Hospital, Hong Kong., Cheung SYS; Department of Surgery, North District Hospital, Hong Kong., Lai PBS; Department of Surgery, The Chinese University of Hong Kong, Hong Kong; Department of Surgery, Prince of Wales Hospital, New Territories, Hong Kong.
Jazyk: angličtina
Zdroj: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland [Surgeon] 2024 Apr; Vol. 22 (2), pp. e100-e108. Date of Electronic Publication: 2023 Dec 11.
DOI: 10.1016/j.surge.2023.11.007
Abstrakt: Background: Hepatectomy is an established treatment for colorectal liver metastasis (CLM) or neuroendocrine liver metastasis. However, its role in non-colorectal non-neuroendocrine liver metastasis (NCNNLM) is controversial. This study aims to compare long-term survival outcomes after hepatectomy between NCNNLM and CLM in a population-based cohort.
Methods: From 2009 to 2018, curative hepatectomy were performed in 964 patients with NCNNLM (n ​= ​133) or CLM (n ​= ​831). Propensity score (PS) matching was performed. Short-term and long-term outcomes were compared between PS-matched groups. Univariate and multivariate analyses were performed to identify prognostic factors affecting survival.
Results: There were 133 patients in the NCNNLM group and 266 patients in the CLM group. The mortality (1.5 ​% vs 1.5 ​%) and morbidity (19.5 ​% vs 20.3 ​%) rates were comparable between the two groups. There was no statistically significant difference in 5-year overall (48.9 ​% vs 39.8 ​%) and recurrence-free (25.1 ​% vs 23.4 ​%) survival rates between NCNNLM and CLM groups. A high pre-operative serum bilirubin level, severe postoperative complications and multiple tumors were independent prognostic factors for poor survival.
Conclusion: Hepatectomy for selected patients with NCNNLM can achieve similar long-term oncological outcomes as those with CLM. High serum bilirubin, severe postoperative complication and multiple tumors are poor prognostic factors for survival.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
(Copyright © 2023 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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