Photodynamic therapy for nodular basal cell carcinoma up to 5mm located on high-risk area: Effectiveness and long-term follow-up results.

Autor: Salvio AG; Skin Department of Amaral Carvalho Hospital, Jaú, SP, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Brazil. Electronic address: gasalvio@hotmail.com., Requena MB; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Brazil., Stringasci MD; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Brazil., Fregolenti BA; Skin Department of Amaral Carvalho Hospital, Jaú, SP, Brazil., Medero MMC; Skin Department of Amaral Carvalho Hospital, Jaú, SP, Brazil., Silva RGS; Skin Department of Amaral Carvalho Hospital, Jaú, SP, Brazil., Bagnato VS; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Brazil; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2024 Feb; Vol. 45, pp. 103919. Date of Electronic Publication: 2023 Dec 09.
DOI: 10.1016/j.pdpdt.2023.103919
Abstrakt: Significance: Response rates evaluation of photodynamic therapy (PDT) for nodular basal cell carcinoma (BCC) treatment located on high-risk and low-risk areas of the face.
Approach: Two groups of nodular BCC were selected, debulked, and received 20% methyl aminolevulinate (MAL) hydrochloride cream. After 3 h, the first irradiation was performed (20 min, 150 J/cm 2 ). Then, the cream was re-applied, and a second irradiation was performed after 1.5 h (20 min, 150 J/cm 2 ). Clearance at 30 days and recurrence-free survival rate were evaluated.
Results: The clearance at 30 days after PDT was 89% for the low-risk area group and 87% for the high-risk group. The recurrence-free survival at 60 months was 82% and 85% for the high-risk and low-risk groups, respectively.
Conclusions: No significant differences were observed between groups nor for clearance at 30 days, nor recurrence-free follow-up. These results make PDT possible option for nodular BCC less than 5 mm located in high-risk areas.
Competing Interests: Declaration of Competing Interest No conflicts of interest to be declared
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: