Photocatalytic Radical Coupling of Organoborates with α-Halogenated Electron-Poor Olefins.
| Autor: | Caldarelli M; Nerviano Medical Sciences Srl, viale Pasteur 10, 20014 Nerviano, Milano, Italy., Rezzi SJ; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy., Colombo N; Accelera Srl, viale Pasteur 10, 20014 Nerviano, Milano, Italy., Pirali T; Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy., Papeo G; Nerviano Medical Sciences Srl, viale Pasteur 10, 20014 Nerviano, Milano, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of organic chemistry [J Org Chem] 2024 Jan 05; Vol. 89 (1), pp. 633-643. Date of Electronic Publication: 2023 Dec 11. |
| DOI: | 10.1021/acs.joc.3c02386 |
| Abstrakt: | Herein, we report the visible-light-mediated addition of organoborates to α-halogenated electron-poor olefins enabled by an environmentally benign metal-free catalyst. The method accommodates a variety of boronic acid derivatives as well as alkenes and delivers the corresponding saturated α-halo-derivatives in up to 90% yields. The obtained products are high-value building blocks in organic synthesis, allowing for a variety of follow-up transformations. |
| Databáze: | MEDLINE |
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