Changes in lipid composition of host-derived extracellular vesicles following Salmonella infection.

Autor:	Emerson LE; Microbiology and Cell Science Department, IFAS, University of Florida , Gainesville, Florida, USA., Mosby CA; Microbiology and Cell Science Department, IFAS, University of Florida , Gainesville, Florida, USA., Enslow S; Microbiology and Cell Science Department, IFAS, University of Florida , Gainesville, Florida, USA., Hui WW; Microbiology and Cell Science Department, IFAS, University of Florida , Gainesville, Florida, USA., Jones MK; Microbiology and Cell Science Department, IFAS, University of Florida , Gainesville, Florida, USA., Ferraro MJ; Microbiology and Cell Science Department, IFAS, University of Florida , Gainesville, Florida, USA.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2024 Jan 11; Vol. 12 (1), pp. e0279623. Date of Electronic Publication: 2023 Dec 11.
DOI:	10.1128/spectrum.02796-23
Abstrakt:	Importance: This study delves into the previously unexplored territory of extracellular vesicle (EV) cargo and composition, specifically focusing on lipid composition changes in EVs following Salmonella infection. EVs play crucial roles in intercellular communication, carrying a variety of biomolecules. Investigating how these EV cargo lipids change post-infection with Salmonella is significant for understanding the molecular mechanisms underlying lipid trafficking during infection. Given the impact of lipid composition on EV function, this research uncovers distinct differences in the lipid profiles of EVs at different time points post-infection and between infected and uninfected macrophages. This study identified lipids that are differentially abundant in EVs produced by the host during infection, offering novel insights into the dynamics of lipid profiles in EVs during cellular processes and infections. This work advances our understanding of host-pathogen interactions, specifically lipid-mediated EV functions during infection. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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