Histone globular domain epigenetic modifications: The regulators of chromatin dynamics in malaria parasite.

Autor: Jabeena CA; Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud P O, Thiruvananthapuram, Kerala, 695014, India., Rajavelu A; Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud P O, Thiruvananthapuram, Kerala, 695014, India.; Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology, Madras, Chennai, Tamil Nadu, 600 036, India.
Jazyk: angličtina
Zdroj: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Feb 16; Vol. 25 (4), pp. e202300596. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1002/cbic.202300596
Abstrakt: Plasmodium species adapt a complex lifecycle with multiple phenotypes to survive inside various cell types of humans and mosquitoes. Stage-specific gene expression in the developmental stages of parasites is tightly controlled in Plasmodium species; however, the underlying mechanisms have yet to be explored. Genome organization and gene expression for each stage of the malaria parasite need to be better characterized. Recent studies indicated that epigenetic modifications of histone proteins play a vital role in chromatin plasticity. Like other eukaryotes, Plasmodium species N-terminal tail modifications form a distinct "histone code," which creates the docking sites for histone reader proteins, including gene activator/repressor complexes, to regulate gene expression. The emerging research findings shed light on various unconventional epigenetic changes in histone proteins' core/globular domain regions, which might contribute to the chromatin organization in different developmental stages of the malaria parasite. The malaria parasite lost many transcription factors during evolution, and it is proposed that the nature of local chromatin structure essentially regulates the stage-specific gene expression. This review highlights recent discoveries of unconventional histone globular domain epigenetic modifications and their functions in regulating chromatin structure dynamics in various developmental stages of malaria parasites.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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