The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer.

Autor:	Götz L; Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Rueckschloss U; Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Balk G; Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Pfeiffer V; Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Ergün S; Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Kleefeldt F; Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany.; Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Nov 24; Vol. 14, pp. 1295232. Date of Electronic Publication: 2023 Nov 24 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1295232
Abstrakt:	The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin superfamily. CEACAM1 was shown to be a prognostic marker in patients suffering from cancer. In this review, we summarize pre-clinical and clinical evidence linking CEACAM1 to tumorigenicity and cancer progression. Furthermore, we discuss potential CEACAM1-based mechanisms that may affect cancer biology. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Götz, Rueckschloss, Balk, Pfeiffer, Ergün and Kleefeldt.)
Databáze:	MEDLINE
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