Negative feedback control of hunger circuits by the taste of food.

Autor:	Aitken TJ; Neuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA., Ly T; Neuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA., Shehata S; Howard Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA., Sivakumar N; Howard Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA., Medina NS; Howard Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA., Gray LA; Howard Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA., Dundar N; Neuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA., Barnes C; Howard Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA., Knight ZA; Department of Physiology, University of California, San Francisco; San Francisco, CA 94158, USA.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco; San Francisco, CA 94158, USA.; Neuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, University of California, San Francisco; San Francisco, CA 94158, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 03. Date of Electronic Publication: 2023 Dec 03.
DOI:	10.1101/2023.11.30.569492
Abstrakt:	The rewarding taste of food is critical for motivating animals to eat, but whether taste has a parallel function in promoting meal termination is not well understood. Here we show that hunger-promoting AgRP neurons are rapidly inhibited during each bout of ingestion by a signal linked to the taste of food. Blocking these transient dips in activity via closed-loop optogenetic stimulation increases food intake by selectively delaying the onset of satiety. We show that upstream leptin receptor-expressing neurons in the dorsomedial hypothalamus (DMH LepR ) are tuned to respond to sweet or fatty tastes and exhibit time-locked activation during feeding that is the mirror image of downstream AgRP cells. These findings reveal an unexpected role for taste in the negative feedback control of ingestion. They also reveal a mechanism by which AgRP neurons, which are the primary cells that drive hunger, are able to influence the moment-by-moment dynamics of food consumption. Competing Interests: Declaration of Interests: The authors declare no competing interests.
Databáze:	MEDLINE
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