Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.
| Autor: | Kulla A; College of Medicine, University of Florida, Gainesville, Florida., Coury S; Department of Psychology, Stanford University, Stanford, California., Garcia JM; Department of Psychology, Stanford University, Stanford, California., Teresi GI; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania., Sisk LM; Department of Psychology, Yale University, New Haven, Connecticut., Hansen M; Department of Psychology, Colorado State University, Fort Collins, Colorado., Miller JG; Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut., Gotlib IH; Department of Psychology, Stanford University, Stanford, California., Ho TC; Department of Psychology, University of California, Los Angeles, Los Angeles, California. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2023 Oct 14; Vol. 4 (1), pp. 61-72. Date of Electronic Publication: 2023 Oct 14 (Print Publication: 2024). |
| DOI: | 10.1016/j.bpsgos.2023.10.002 |
| Abstrakt: | Background: Neighborhood- or area-level socioeconomic disadvantage is associated with neural alterations across the life span. However, few studies have examined the effects of neighborhood disadvantage on white matter microstructure during adolescence, an important period of development that coincides with increased risk for psychopathology. Methods: In 200 adolescents (ages 13-20 years; 54.5% female, 4% nonbinary) recruited from 2 studies enriched for early adversity and depression, we examined whether neighborhood socioeconomic disadvantage derived from census tract data was related to white matter microstructure in several major white matter tracts. We also examined whether depressive symptoms and sex moderated these associations. Results: Greater neighborhood socioeconomic disadvantage was associated with lower fractional anisotropy (FA) in the left arcuate fasciculus (β = -0.24, false discovery rate [FDR]-corrected p = .035) and right uncinate fasciculus (β = -0.32, FDR-corrected p = .002) above and beyond the effects of family-level socioeconomic status. Depressive symptoms significantly moderated the association between left arcuate fasciculus FA and both neighborhood (β = 0.17, FDR-corrected p = .026) and unemployment (β = 0.22, FDR-corrected p = .004) disadvantage such that these associations were only significant in adolescents who reported less severe depression. Sex did not moderate the association between socioeconomic disadvantage and FA in these tracts. Conclusions: Greater neighborhood socioeconomic disadvantage, particularly poverty and educational attainment levels, was associated with lower FA in the arcuate fasciculus and uncinate fasciculus above and beyond the effects of family-level measures of socioeconomic status. These patterns were only observed in adolescents with low levels of depression, suggesting that we must be cautious about generalizing these findings to youths who struggle with mental health difficulties. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|