Prevalence of prediabetes in Mexico: a retrospective analysis of nationally representative surveys spanning 2016-2022.

Autor:	Fermín-Martínez CA; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; MD/PhD (PECEM) Program, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Paz-Cabrera CD; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; Especialidad en Medicina Preventiva, Instituto Nacional de Salud Pública, Mexico City, Mexico., Basile-Alvarez MR; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Castro PS; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Núñez-Luna A; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Perezalonso-Espinosa J; Especialidad en Medicina Preventiva, Instituto Nacional de Salud Pública, Mexico City, Mexico., Ramírez-García D; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Antonio-Villa NE; Departmento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Vargas-Vázquez A; Especialidad en Medicina Preventiva, Instituto Nacional de Salud Pública, Mexico City, Mexico., Fernández-Chirino L; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico., Carrillo-Herrera KB; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Cabrera-Quintana LA; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Rojas-Martínez R; Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico., Seiglie JA; Diabetes Unit, Massachusetts General Hospital, Harvard Medical School, MA, USA.; Department of Medicine, Harvard Medical School, MA, USA., Bello-Chavolla OY; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Lancet regional health. Americas [Lancet Reg Health Am] 2023 Nov 24; Vol. 28, pp. 100640. Date of Electronic Publication: 2023 Nov 24 (Print Publication: 2023).
DOI:	10.1016/j.lana.2023.100640
Abstrakt:	Background: Characterizing prediabetes phenotypes may be useful in guiding diabetes prevention efforts; however, heterogeneous criteria to define prediabetes have led to inconsistent prevalence estimates, particularly in low- and middle-income countries. Here, we estimated trends in prediabetes prevalence in Mexico across different prediabetes definitions and their association with prevalent cardiometabolic conditions. Methods: We conducted a serial cross-sectional analysis of National Health and Nutrition Surveys in Mexico (2016-2022), totalling 22 081 Mexican adults. After excluding individuals with diagnosed or undiagnosed diabetes, we defined prediabetes using ADA (impaired fasting glucose [IFG] 100-125 mg/dL and/or HbA1c 5.7-6.4%), WHO (IFG 110-125 mg/dL), and IEC criteria (HbA1c 6.0-6.4%). Prevalence trends of prediabetes over time were evaluated using weighted Poisson regression and its association with prevalent cardiometabolic conditions with weighted logistic regression. Findings: The prevalence of prediabetes (either IFG or high HbA1c [ADA]) in Mexico was 20.9% in 2022. Despite an overall downward trend in prediabetes (RR 0.973, 95% CI 0.957-0.988), this was primarily driven by decreases in prediabetes by ADA-IFG (RR 0.898, 95% CI 0.880-0.917) and WHO-IFG criteria (RR 0.919, 95% CI 0.886-0.953), while prediabetes by ADA-HbA1c (RR 1.055, 95% CI 1.033-1.077) and IEC-HbA1C criteria (RR 1.085, 95% CI 1.045-1.126) increased over time. Prediabetes prevalence increased over time in adults >40 years, with central obesity, self-identified as indigenous or living in urban areas. For all definitions, prediabetes was associated with an increased risk of cardiometabolic conditions. Interpretation: Prediabetes rates in Mexico from 2016 to 2022 varied based on defining criteria but consistently increased for HbA1c-based definitions and high-risk subgroups. Funding: This research was supported by Instituto Nacional de Geriatría in Mexico. JAS was supported by NIH/NIDDK Grant# K23DK135798. Competing Interests: The authors declare that they have no competing interests. (© 2023 The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu