Demographic characteristics, laboratory features and complications in 346 cases of brucellosis: A retrospective study from Qatar.

Autor:	Varikkodan I; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar., Naushad VA; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.; Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar., Purayil NK; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.; Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar., Zahid M; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.; Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar., Sirajudeen J; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.; Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar., Ambra N; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar., Mohammed AM; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar., Trivedi J; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar., Kandalam SP; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar., Joseph P; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar., Kartha AB; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.; Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar., Elzouki A; Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.; Department of Clinical Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	IJID regions [IJID Reg] 2023 Nov 15; Vol. 10, pp. 18-23. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2024).
DOI:	10.1016/j.ijregi.2023.11.007
Abstrakt:	Objectives: To study the epidemiology and laboratory findings and outcomes of human brucellosis in the state of Qatar. Methods: A retrospective study involving adult patients with a definitive diagnosis of brucellosis was conducted. Results: Of the 346 patients 299 were males. The mean age was 39.62 years. 120 patients had history of drinking raw milk and 116 had a history of contact with animals. Fever (89.9%) and myalgia (56.6%) were the most common presenting symptoms observed. Raised C-reactive protein level was the most frequent laboratory finding noted. Alanine aminotransferase and aspartate aminotransferase levels were raised to three times the normal in 39.6% and 37% of patients, respectively. Blood culture was positive in 72.8% whereas Brucella immunoglobulin G antibody and immunoglobulin M antibody titer was positive in 72.5% and 73.1% patients, respectively. Approximately 21.4% had focal involvement and osteoarticular (11.6%) involvement was the most frequently observed focal form. Doxycycline with rifampicin or gentamicin was the common regimen received. Relapse was seen in 7.2% patients. Conclusion: Human brucellosis continues to be a serious health issue in Qatar predominantly affecting healthy young adult men resulting in significant morbidity. Preventive measures and community awareness particularly among high-risk groups will help in decreasing the prevalence of the disease and its aftereffects. Competing Interests: The authors have no competing interests to declare. (© 2023 The Author(s).)
Databáze:	MEDLINE
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