Effect of cardiopulmonary bypass on thiol/disulfide homeostasis in congenital heart surgery.

Autor:	Tanyildiz M; Department of Pediatric Intensive Care, Koç University School of Medicine, Istanbul, Türkiye., Yetimakman AF; Department of Pediatric Intensive Care, Hacettepe University School of Medicine, Ankara Türkiye., Yazici MU; Department of Pediatric Intensive Care, Hacettepe University School of Medicine, Ankara Türkiye., Kumbasar U; Department of Cardiovascular Surgery, Hacettepe University School of Medicine, Ankara Türkiye., Alisik M; Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, Türkiye., Oguz S; Department of Pediatric Intensive Care, Koç University School of Medicine, Istanbul, Türkiye., Bicer M; Department of Cardiovascular Surgery, Koç University School of Medicine, Istanbul, Türkiye., Bayrakci B; Department of Pediatric Intensive Care, Hacettepe University School of Medicine, Ankara Türkiye., Erel O; Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, Türkiye.
Jazyk:	angličtina
Zdroj:	Turk gogus kalp damar cerrahisi dergisi [Turk Gogus Kalp Damar Cerrahisi Derg] 2023 Oct 19; Vol. 31 (4), pp. 454-466. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
DOI:	10.5606/tgkdc.dergisi.2023.25283
Abstrakt:	Background: This study aims to investigate whether thiol/disulfide homeostasis parameters measurements could be used as a new biomarker to predict the pre- and post-cardiopulmonary bypass oxidative status of pediatric patients undergoing congenital heart surgery. Methods: A total of 40 children with congenital heart disease (17 males, 23 females; mean age: 39.6±40.0 months; range, 2 to 216 months) who underwent open-heart surgery were included. The control group consisted of 40 age- and sex-matched healthy children (18 males, 22 females; mean age: 42.8±46.6 months; range, 12 to 156 months). The patients with congenital heart disease were divided into two groups as cyanotic patients (n=18) and acyanotic patients (n=22). Thiol/disulfide parameters were compared among the cyanotic, acyanotic congenital heart disease patients, and control group preoperatively (pre-CPB). The effects of cardiopulmonary bypass on thiol/disulfide parameters, pre-CBP, immediately after cardiopulmonary bypass (post-CPB0), and 24 h after cardiopulmonary bypass (post-CPB24) were investigated. Results: The mean native and total thiol levels in the cyanotic patients were significantly lower than those in the acyanotic patients and control group (p<0.0001). The cyanotic group exhibited higher disulfide levels than the acyanotic group (p<0.01). The mean native thiol and total thiol levels significantly decreased in the post-CPB0 (p<0.0001). The mean disulfide levels significantly increased in the post-CPB0 than the pre-CPB values (p<0.001). Post-CPB24 native and total thiol levels were elevated compared to post-CPB0 (p<0.0001). The mean disulfide levels significantly increased in the post-CPB24 period than the post-CPB0 values (p<0.001). The survivor patients responded better to oxidative stress than non-survivor patients. Conclusion: Thiol/disulfide measurement is a promising biomarker in determining the pre- and post-cardiopulmonary bypass oxidative status of pediatric patients undergoing congenital heart surgery. The interpretation of thiol/disulfide levels, pre- and postoperatively, may be used in predicting mortality and outcomes of these patients earlier. Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article. (Copyright © 2023, Turkish Society of Cardiovascular Surgery.)
Databáze:	MEDLINE
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