The frequency of IgG anti-varicella and anti-rubella antibodies in female students of Shiraz University of Medical Sciences, Iran.

Autor:	Hashemi SMA; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran., Alipour AH; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Teheran, Iran., Khatab Z; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran., Maleki S; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran., Nekooei F; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran., Dashtizadeh F; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran., Daryabor GR; Autoimmune Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Kalantar K; Autoimmune Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran., Salimi V; Department of Virology, Tehran University of Medical Sciences, Tehran, Iran., Sarvari J; Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.; Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk:	angličtina
Zdroj:	Le infezioni in medicina [Infez Med] 2023 Dec 01; Vol. 31 (4), pp. 533-538. Date of Electronic Publication: 2023 Dec 01 (Print Publication: 2023).
DOI:	10.53854/liim-3104-12
Abstrakt:	Background: As infection with rubella and varicella-zoster viruses (VZV) can lead to congenital syndrome and its dangerous complications, assessing immunity to these congenital infections can represent the biological risk assessment related to their exposure in high-risk groups. Therefore, we aimed to evaluate the frequency of IgG anti-varicella/rubella antibodies (Abs) in female students at Shiraz University of Medical Sciences (SUMS), Iran. Patients and Methods: In this study, a total of 434 female students were included. Sera were isolated from blood samples and stored at -20°C for later analysis. A questionnaire form was documented and contained demographic data as well as the history of vaccinations. Enrolled students were divided into recipients of either one or two doses of the measles/rubella (MR) vaccine. Serum samples were analyzed for rubella and VZV IgG Abs using commercial IgG immunoassays. Results: The students were 21.6±4.25 years old on average. Out of the 434 enrolled students, 292 (67.3%) and 287 (66.1%) students were positive for anti-varicella and anti-rubella IgG-Abs, respectively. The frequency of anti-rubella IgG Ab was significantly higher in those who received one dose of MR vaccine (P<0.001). In addition, 205 (47.2%) and 59 (13.6%) students were double-positive (anti-varicella/rubella IgG Abs) and double-negative, respectively. Conclusion: Our results indicated that an additional dose of rubella vaccine may be required for those who received two doses of the vaccine. In addition, we recommend the inclusion of the VZV vaccine in Iran's routine vaccination program. Further studies are recommended to verify these results. Competing Interests: Conflict of interest: The authors declare that they have no competing interests.
Databáze:	MEDLINE
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