Trimodal therapy versus radical cystectomy for cT2N0M0 urothelial muscle-invasive bladder cancer: Single-center experience.

Autor: Fallatah M; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Alkahtani AS; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Alrumayyan M; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Alotaibi MF; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Alkhateeb S; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Mokhtar AA; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia., Altaweel W; Department of Urology, King Faisal Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Jazyk: angličtina
Zdroj: Urology annals [Urol Ann] 2023 Oct-Dec; Vol. 15 (4), pp. 406-411. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.4103/ua.ua_50_23
Abstrakt: Background: Bladder cancer is ranked the ninth most common cancer in the world. Locally, the incidence of bladder cancer has increased tenfold over the past 26 years. Radical cystectomy (RC) is considered a gold standard management option for muscle-invasive bladder cancer (MIBC), but trimodal therapy (TMT) has shown comparable oncological outcomes in selected patients.
Materials and Methods: This is a retrospective study in which we reviewed medical records of patients diagnosed with MIBC without nodal disease or distant metastasis (cT2N0M0) who underwent either RC or TMT. Demographic data, comorbidities, histopathological and clinical staging, neoadjuvant/adjuvant therapy, and follow-up were analyzed.
Results: We included a total of 31 patients in the study, with 10 patients in the TMT group and 21 patients in the RC group. There was no significant difference in recurrence between the TMT and RC groups ( P = 0.58). The TMT group had a higher percentage of local recurrence (40% vs. RC 5.2%, P = 0.018) but no significant difference in metastasis (0% vs. 10%, P = 0.420). The difference in overall survival between the TMT and RC groups was not significant ( P = 0.25).
Conclusion: TMT may be considered an alternative option for patients unwilling to undergo RC due to related complications and prioritize a better quality of life. However, the decision should be made after considering the cost of extensive follow-ups and patient compliance with surveillance.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Urology Annals.)
Databáze: MEDLINE
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