| Autor: |
Vega-Jiménez AL; Laboratorio de Bioingeniería de Tejidos. Facultad de Odontología, Universidad Nacional Autónoma de México., González-Alva P; Laboratorio de Bioingeniería de Tejidos. Facultad de Odontología, Universidad Nacional Autónoma de México., Rodríguez-Hernández AP; Laboratorio de Genética Molecular Facultad de Odontología, Universidad Nacional Autónoma de México., Vázquez-Olmos AR; Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México., Paz-Díaz B; Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México. |
| Jazyk: |
angličtina |
| Zdroj: |
Dental materials journal [Dent Mater J] 2024 Jan 30; Vol. 43 (1), pp. 11-19. Date of Electronic Publication: 2023 Dec 08. |
| DOI: |
10.4012/dmj.2023-041 |
| Abstrakt: |
Functional nano-fillers are commonly used to reduce bacterial colonization in dentistry. This study aimed to synthesize, characterize, and evaluate the biological effects of magnesium oxide (MgO) nanoparticles (NP) obtained by mechanosynthesis. XRD, TEM, FT-IR, and UV-Vis were used to characterize MgO-NP which were subsequently tested for their activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (E. coli). The effects of MgO-NP on osteoblast cells were also analyzed. Three variables were studied: microbial inhibition by optical density (OD; 570-nm), viability estimated by colony-forming-units, and cell proliferation. The characterization of NP is consistent with nanostructures, minimum inhibitory concentration between 1.5-5 mg/mL, and microbial inhibition at 9.75 ug/mL concentration for E. coli were determined. There were different concentration-dependent effects on cell proliferation. Results were observed with 0.156 mg/mL MgO-NP, which increased cell proliferation at 24 and 48 h. The results suggest the antibacterial suitability of MgO-NP, with tolerable viability of mammalian cells for dental applications. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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