Mygalin, an Acanthoscurria gomesiana spider-derived synthetic, modulates haloperidol-induced cataleptic state in mice.

Autor: Santos GX; Physiotherapy Department, Federal University of Alfenas (UNIFAL), Alfenas, Brazil., Dos SantosTeodoro JE; Physiotherapy Department, Federal University of Alfenas (UNIFAL), Alfenas, Brazil., Fonseca MG; Physiotherapy Department, Federal University of Alfenas (UNIFAL), Alfenas, Brazil., Acunha RM; Laboratory of Neurosciences of Pain & Emotions and Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo, Av. Bandeirantes 3900 Ribeirão Preto, São Paulo 14049-900, Brazil., da Silva Júnior PI; Laboratory for Applied Toxinology (LETA), Butantan Institute, Sao Paulo, SP 05503-900, Brazil., Reis LMD; Physiotherapy Department, Federal University of Alfenas (UNIFAL), Alfenas, Brazil. Electronic address: reislucianamaria@g.com., de Freitas RL; Laboratory of Neurosciences of Pain & Emotions and Multi-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo, Av. Bandeirantes 3900 Ribeirão Preto, São Paulo 14049-900, Brazil; Interdisciplinary Center for Pain Care, Federal University of São Carlos (UFSCar), Universidade Federal de São Carlos, Rodovia Washington Luiz, Km 235, Caixa Postal 676, CEP 13565-905, SP, Brazil; Behavioural Neurosciences Institute (INeC), Av. do Café 2450 Ribeirão Preto, São Paulo 14050-220, Brazil., Medeiros P; Interdisciplinary Center for Pain Care, Federal University of São Carlos (UFSCar), Universidade Federal de São Carlos, Rodovia Washington Luiz, Km 235, Caixa Postal 676, CEP 13565-905, SP, Brazil; Department of General and Specialized Nursing - EERP/USP Ribeirão Preto College of Nursing - USP, Brazil; Behavioural Neurosciences Institute (INeC), Av. do Café 2450 Ribeirão Preto, São Paulo 14050-220, Brazil. Electronic address: priscila.neuro@usp.br.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2024 Jan 18; Vol. 820, pp. 137572. Date of Electronic Publication: 2023 Dec 09.
DOI: 10.1016/j.neulet.2023.137572
Abstrakt: Background: Haloperidol (HAL) is an antipsychotic used in the treatment of schizophrenia. However, adverse effects are observed in the extrapyramidal tracts due to its systemic action. Natural compounds are among the treatment alternatives widely available in Brazilian biodiversity. Mygalin (MY), a polyamine that was synthesized from a natural molecule present in the hemolymph of the Acanthoscurria gomesian spider, may present an interesting approach.
Aims: This study aimed to evaluate the effect of MY in mice subjected to HAL-induced catalepsy.
Methods: Male Swiss mice were used. Catalepsy was induced by intraperitoneal administration of HAL (0.5 mg/kg - 1 mL/Kg) diluted in physiological saline. To assess the MY effects on catalepsy, mice were assigned to 4 groups: (1) physiological saline (NaCl 0.9 %); (2) MY at 0.002 mg/Kg; (3) MY at 0.02 mg/Kg; (4) MY at 0.2 mg/Kg. MY or saline was administered intraperitoneally (IP) 10 min b HAL before saline. Catalepsy was evaluated using the bar test at 15, 30, 60, 90, and 120 min after the IP administration of HAL.
Results: The latency time in the bar test 15, 30, 60, and 90 min increased (p < 0.05) after IP administration of HAL compared to the control group. Catalepsy was attenuated 15, 30, 90, and 120 min (p < 0.05) after the IP-administration of MY at 0.2 mg/Kg; while MY at 0.02 mg/Kg attenuated catalepsy 15 min after the HAL treatment. Our findings showed that MY attenuates the HAL-induced cataleptic state in mice.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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