Emerging trends in the inhibition of bacterial molecular communication: An overview.

Autor: Maha Swetha BR; Department of Biotechnoloy, Srimad Andavan Arts and Science College (Autonomous), Tiruchirappalli, Tamil Nadu, India., Saravanan M; Department of Physics, University College of Engineering, Bharathidasan Institute of Technology Campus, Anna University, Tiruchirapalli, 620 024, Tamil Nadu, India., Piruthivraj P; Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha Univerisy, Chennai, 600 077, Tamil Nadu, India; Department of Biotechnoloy, Srimad Andavan Arts and Science College (Autonomous), Tiruchirappalli, Tamil Nadu, India. Electronic address: prakash@andavancollege.ac.in.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2024 Jan; Vol. 186, pp. 106495. Date of Electronic Publication: 2023 Dec 07.
DOI: 10.1016/j.micpath.2023.106495
Abstrakt: Quorum sensing (QS) is a molecular cell-cell communication utilized by several bacteria and some fungi. It involves cell density dependent gene expression that includes extra polymeric substance production, sporulation, antibiotic production, motility, competence, symbiosis and conjugation. These expressions were carried out by different signaling molecules like acyl homo-serine lactone (AHL) and auto-inducing peptides (AIPs) which was effluxed by gram negative and gram positive bacteria. Pathogenic bacteria and biofilms often exhibit high resistance to antibiotics, attributed to the presence of antibiotic efflux pumps, reduced membrane permeability, and enzymes that deactivate quorum sensing (QS) inhibitors. To counteract virulence and multi-drug resistance (MDR), novel strategies such as employing quorum sensing (QS) inhibitors and quorum quenchers are employed. It targets signaling molecules with synthesis and prevents the signal from binding to receptors. In this present review, the mechanisms of QS along with inhibitors from different sources are described. These strategies potentially interfere with QS and it can be applied in different fields, mainly in hospitals and marine environments where the pathogenic infections and biofilm formation are highly involved.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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