Effect of zinc oxide micro- and nanoparticles on cytotoxicity, antimicrobial activity and mechanical properties of apatite-polymer osteoplastic material.

Autor: Sukhodub L; Sumy State University, 2 Rymskogo-Korsakova st., 40007, Sumy, Ukraine. Electronic address: l.sukhodub@gmail.com., Kumeda M; Sumy State University, 2 Rymskogo-Korsakova st., 40007, Sumy, Ukraine., Sukhodub L; Sumy State University, 2 Rymskogo-Korsakova st., 40007, Sumy, Ukraine., Vovchenko L; Department of Physics, Taras Shevchenko National University of Kyiv, Volodymyrska str., 64/13, 01601, Kyiv, Ukraine., Prokopiuk V; Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavska Street, 23, 61015, Kharkiv, Ukraine., Petrenko O; Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavska Street, 23, 61015, Kharkiv, Ukraine., Kovalenko I; Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Pereyaslavska Street, 23, 61015, Kharkiv, Ukraine., Pshenychnyi R; Sumy State University, 2 Rymskogo-Korsakova st., 40007, Sumy, Ukraine., Opanasyuk A; Sumy State University, 2 Rymskogo-Korsakova st., 40007, Sumy, Ukraine.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Feb; Vol. 150, pp. 106289. Date of Electronic Publication: 2023 Dec 06.
DOI: 10.1016/j.jmbbm.2023.106289
Abstrakt: This work is devoted to the comparison of the physical and biological properties of synthesized osteoplastic composites with an experimentally determined content (375 μg/g) of the micro (ZnO MPs ) and nano (ZnO NPs ) particles, immobilized in Hydroxyapatite-Alginate-Chitosan matrix (HA-Alg-CS). ZnO NPs show pronounced antimicrobial activity against E.coli ATCC 25922 and S. aureus ATCC 25923, while ZnO MPs only in the CS presence. Composites containing ZnO NPs/MPs do not have a toxic effect on bone-forming cells - osteoblasts, preserving their ability to biomineralization. ZnO MPs and ZnO NPs to varying degrees, but significantly affect composites' swelling, porosity, shape stability, and prolong vitamin D3 release for 120h, compared to Control. Composites do not demonstrate unwanted "burst release." ZnO NPs/MPs increase Youngs' modulus of the HA-Alg matrix, namely 348 → 419 MPa (ZnO MPs ), 348 → 646 MPa (ZnO NPs ), and weaken the plastic (irreversible) deformations. The compressive strength of HA-Alg and HA-Alg/CS matrixes containing ZnO NPs (178 MPa and 251 MPa, respectively) is in the range of values for native cortical bone (170-193 MPa). Biocompatibility and lack of toxic effect give both composites a perspective for osteoplastic application, but composites doped with ZnO NPs are more attractive.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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