The dual role of MiR-210 in the aetiology of cancer: A focus on hypoxia-inducible factor signalling.

Autor: Afsar S; Department of Virology, Sri Venkateswara University, Tirupathi, Andhra Pradesh 517502, India., Syed RU; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia. Electronic address: ru.syed@uoh.edu.sa., Bin Break MK; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia; Medical and Diagnostic Research Centre, University of Hail, Hail 55473, Saudi Arabia., Alsukaybi RH; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alanzi RA; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alshobrmi AM; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alshagdali NM; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alshammari AD; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alharbi FM; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alshammari AM; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Algharbi WF; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Albrykan KM; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia., Alshammari FN; College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia. Electronic address: faihaalsh62@outlook.com.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Jan; Vol. 253, pp. 155018. Date of Electronic Publication: 2023 Dec 06.
DOI: 10.1016/j.prp.2023.155018
Abstrakt: Tumorigenesis exemplifies the complex process of neoplasm origination, which is characterised by somatic genetic alterations and abnormal cellular growth. This multidimensional phenomenon transforms previously dormant cells into malignant equivalents, resulting in uncontrollable proliferation and clonal expansion. Various elements, including random mutations, harmful environmental substances, and genetic predispositions, influence tumorigenesis's aetiology. MicroRNAs (miRNAs) are now recognised as crucial determinants of gene expression and key players in several biological methods, including oncogenesis. A well-known hypoxia-inducible miRNA is MiR-210, which is of particular interest because of its complicated role in the aetiology of cancer and a variation of physiological and pathological situations. MiR-210 significantly impacts cancer by controlling the hypoxia-inducible factor (HIF) signalling pathway. By supporting angiogenesis, metabolic reprogramming, and cellular survival in hypoxic microenvironments, HIF signalling orchestrates adaptive responses, accelerating the unstoppable development of tumorous growth. Targeting several components of this cascade, including HIF-1, HIF-3, and FIH-1, MiR-210 plays a vital role in modifying HIF signalling and carefully controlling the HIF-mediated response and cellular fates in hypoxic environments. To understand the complexities of this relationship, careful investigation is required at the intersection of MiR-210 and HIF signalling. Understanding this relationship is crucial for uncovering the mechanisms underlying cancer aetiology and developing cutting-edge therapeutic approaches. The current review emphasises MiR-210's significance as a vital regulator of the HIF signalling cascade, with substantial implications spanning a range of tumor pathogenesis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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