The effect of potassium supplementation and concomitant medications on potassium homeostasis for hospitalized patients.

Autor:	Montepara CA; Division of Pharmacy Practice, Duquesne University School of Pharmacy, Pittsburgh, PA.; Allegheny General Hospital, Pittsburgh, PA, USA., Bortmas MR; Duquesne University School of Pharmacy, Pittsburgh, PA, USA., Cochenour CJ; Duquesne University School of Pharmacy, Pittsburgh, PA, USA., Fleming MK; Duquesne University School of Pharmacy, Pittsburgh, PA, USA., Gaffey SH; Duquesne University School of Pharmacy, Pittsburgh, PA, USA., McQuigg MA; Duquesne University School of Pharmacy, Pittsburgh, PA, USA., Parisi MK; Duquesne University School of Pharmacy, Pittsburgh, PA, USA., Zimmerman DE; Division of Pharmacy Practice, Duquesne University School of Pharmacy, Pittsburgh, PA, and UPMC Mercy Hospital, Pittsburgh, PA, USA., Covvey JR; Division of Pharmaceutical, Administrative, and Social Sciences, Duquesne University School of Pharmacy, Pittsburgh, PA, USA., Nemecek BD; Division of Pharmacy Practice, Duquesne University School of Pharmacy, Pittsburgh, PA, and UPMC Mercy Hospital, Pittsburgh, PA, USA.
Jazyk:	angličtina
Zdroj:	American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2024 Mar 07; Vol. 81 (6), pp. 183-189.
DOI:	10.1093/ajhp/zxad310
Abstrakt:	Purpose: Hospitalized patients receive potassium (K+) supplementation for hypokalemia, with clinicians often estimating a rise in serum K+ levels of 0.1 mEq/L per 10 mEq delivered. However, there is limited evidence to support this expectation. Patients also concomitantly take medications that may alter K+ levels, and it is not known to what degree these may impact interventions to correct K+ levels via supplementation. The objective of this study was to identify the impact of oral and/or intravenous K+ supplementation on serum K+ levels, including the influence of selected concomitant medications, in adult hospitalized patients. Methods: A single-center, retrospective descriptive study of adult hospitalized patients receiving K+ supplementation at a tertiary hospital between 2021 and 2022 was conducted. Patients were included if they received at least one dose of potassium chloride while admitted to the general medicine ward. The primary outcome was the daily median change in serum K+, normalized per 10 mEq of supplementation administered. The secondary outcome was the impact of selected concomitant medication use on supplement-induced changes in serum K+. Results: A total of 800 patients and 1,291 daily episodes of K+ supplementation were evaluated. The sample was approximately 53% women, was 78% white, and had a median age of 68 years. The overall daily median change in serum K+ level was 0.05 mEq/L per 10 mEq of supplementation delivered. Patients received a median of 40 mEq of supplementation per day, primarily via the oral route (80.6%). Among the concomitant medications assessed, loop diuretics significantly dampened the impact of K+ supplementation. Conclusion: Supplementation of K+ in non-critically ill hospitalized patients is variable and dependent on concomitant medication use. (© American Society of Health-System Pharmacists 2023. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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