Metabolomics in Ecology and Bioactive Natural Products Discovery: Challenges and Prospects for a Comprehensive Study of the Specialised Metabolome.

Autor:	Wolfender JL; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland. jean-luc.wolfender@unige.ch.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland., Gaudry A; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland., Rutz A; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland., Quiros-Guerrero LM; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland., Nothias LF; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland., Ferreira Queiroz E; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland., Defossez E; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.; Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland., Allard PM; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU, CH-1211 Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, , CH-1211 Genève 4, Switzerland.; Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland.
Jazyk:	angličtina
Zdroj:	Chimia [Chimia (Aarau)] 2022 Nov 30; Vol. 76 (11), pp. 954-963. Date of Electronic Publication: 2022 Nov 30.
DOI:	10.2533/chimia.2022.954
Abstrakt:	Metabolomics is playing an increasingly prominent role in chemical ecology and in the discovery of bioactive natural products (NPs). The identification of metabolites is a common/central objective in both research fields. NPs have significant biological properties and play roles in multiple chemical-ecological interactions. Classically, in pharmacognosy, their chemical structure is determined after a complex process of isolating and interpreting spectroscopic data. With the advent of powerful analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) the annotation process of the specialised metabolome of plants and microorganisms has improved considerably. In this article, we summarise the possibilities opened by these advances and illustrate how we harnessed them in our own research to automate annotations of NPs and target the isolation of key compounds. In addition, we are also discussing the analytical and computational challenges associated with these emerging approaches and their perspective. (Copyright 2022 Jean-Luc Wolfender, Arnaud Gaudry, Adriano Rutz, Luis-Manuel Quiros-Guerrero, Louis-Félix Nothias, Emerson Ferreira Queiroz, Emmanuel Defossez, Pierre-Marie Allard. License: This work is licensed under a Creative Commons Attribution 4.0 International License.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu