Graphene-Based Electrochemical Sensing Platform for Rapid and Selective Ferulic Acid Quantification.

Autor: Mǎgeruşan L; National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, 400293 Cluj-Napoca, Romania., Pogǎcean F; National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, 400293 Cluj-Napoca, Romania., Soran ML; National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, 400293 Cluj-Napoca, Romania., Pruneanu SM; National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, 400293 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 29; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 29.
DOI: 10.3390/ijms242316937
Abstrakt: Due to the multitude of physiological functions, ferulic acid (FA) has a wide range of applications in the food, cosmetic, and pharmaceutical industries. Thus, the development of rapid, sensitive, and selective detection tools for its assay is of great interest. This study reports a new electroanalytical approach for the quantification of ferulic acid in commercial pharmaceutical samples using a sulphur-doped graphene-based electrochemical sensing platform. The few-layer graphene material (exf-SGR) was prepared by the electrochemical oxidation of graphite, at a low applied bias (5 V), in an inorganic salt mixture of Na 2 S 2 O 3 /(NH 4 ) 2 SO 4 (0.3 M each). According to the morpho-structural characterization of the material, it appears to have a high heteroatom doping degree, as proved by the presence of sulphur lines in the XRD pattern, and the C/S ratio was determined by XPS investigations to be 11.57. The electrochemical performances of a glassy carbon electrode modified with the exf-SGR toward FA detection were tested by cyclic voltammetry in both standard laboratory solutions and real sample analysis. The developed modified electrode showed a low limit of detection (30.3 nM) and excellent stability and reproducibility, proving its potential applicability as a viable solution in FA qualitative and quantitative analysis.
Databáze: MEDLINE
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