The Psychological, Social and Behavioral Impact of Intravitreal Anti-VEGF Therapy: An Analysis from the ALBATROS Data.

Autor: Wolfram C; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany., Pfeiffer N; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany., Hudde T; Eye Hospital Wolfsburg-Fallersleben, Am Spieker 10, 38440 Wolfsburg, Germany., Klatt A; Eye Center Klatt, Henry-Wetjen-Platz 3, 28844 Weyhe, Germany., Schnegelsberg B; Novartis Pharma GmbH, Roonstr. 25, 90429 Nuremberg, Germany., Ross M; Novartis Pharma GmbH, Roonstr. 25, 90429 Nuremberg, Germany., Ziemssen F; Department of Ophthalmology, Leipzig University Hospital, University of Leipzig, Liebigstraße 12, Haus 1, 04109 Leipzig, Germany.; Center for Ophthalmology, Eberhard-Karls-Universität Tübingen, Elfriede-Aulhorn-Str. 7, 72076 Tübingen, Germany., Schuster AK; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Nov 30; Vol. 12 (23). Date of Electronic Publication: 2023 Nov 30.
DOI: 10.3390/jcm12237435
Abstrakt: Background: Retinal diseases such as neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), or branch/central retinal vein occlusion (B/CRVO) have significant implications for patients' social and psychological well-being. The ALBATROS study aimed to assess the care situation of patients who received anti-VEGF (vascular endothelial growth factor) treatment. To gain a comprehensive understanding of patients' backgrounds and attitudes, we developed an exploratory, structured questionnaire, the Basic Care and Patient Satisfaction Questionnaire (BPZ-9).
Methods: The data collection took place at the beginning and after twelve months of anti-VEGF therapy. The BPZ-9 questionnaire comprises nine questions to evaluate patients' psychological and social situation and satisfaction with treatment.
Results: Data were collected from 1478 nAMD (mean 78 years), 445 DME (67 years), 233 BRVO (70 years), and 144 CRVO (71 years) patients at 102 study centers throughout Germany. One in four patients had difficulties walking, and one in five needed an accompanying person for treatment. Anxiety about losing vision was present in three out of four patients at the beginning, and it slightly decreased to two out of three patients over the 12-month treatment period. The distress of having a retinal disease was generally higher than the distress related to the treatment. Most patients reported high treatment satisfaction (73%) and felt well-informed (81%).
Conclusions: There is a relevant social and psychological impact related to anti-VEGF treatment. The patients' perception, attitudes, and commitment need further investigation.
Databáze: MEDLINE
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