| Autor: |
Zhou J; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.; Department of Radiological Sciences, University of California, Irvine, CA 92697, USA., Jin Y; Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Miao H; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Lu S; Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Liu X; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., He Y; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Liu H; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Zhao Y; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Zhang Y; Department of Radiological Sciences, University of California, Irvine, CA 92697, USA., Liu YL; Department of Radiological Sciences, University of California, Irvine, CA 92697, USA., Pan Z; Zhejiang Engineering Research Center of Intelligent Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Chen JH; Department of Radiological Sciences, University of California, Irvine, CA 92697, USA., Wang M; Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China., Su MY; Department of Radiological Sciences, University of California, Irvine, CA 92697, USA.; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 840203, Taiwan. |
| Abstrakt: |
A total of 457 patients, including 241 HR+/HER2- patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were 82% in the HR+ patients, 63% in the HER2+ patients, and 56% in the TN patients ( p < 0.001). MRI features such as morphology as mass or non-mass enhancement (NME), shape, margin, internal enhancement, presence of peritumoral edema, and the DCE kinetic pattern were assessed. Tumor sizes were smaller in the HR+/HER2- group ( p < 0.001); HER2+ was more likely to present as NME ( p = 0.031); homogeneous enhancement was mostly seen in HR+ ( p < 0.001); and the peritumoral edema was present in 45% HR+, 71% HER2+, and 80% TN ( p < 0.001). In each subtype, the MR features between the high- vs. low-TIL groups were compared. In HR+/HER2-, peritumoral edema was more likely to be present in those with high TILs (70%) than in those with low TILs (40%, p < 0.001). In TN, those with high TILs were more likely to present a regular shape (33%) than those with low TILs (13%, p = 0.029) and more likely to present the circumscribed margin (19%) than those with low TILs (2%, p = 0.009). |
