The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia.

Autor: Nicholas J; Department of Psychology, Columbia University, New York, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, Quad 3D, 3227 Broadway, New York, NY, 10027, USA., Amlang C; Department of Neurology, Columbia University Medical Center, 650 W. 168th St, Rm 305, New York, NY, 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University Medical Center, New York, NY, USA., Lin CR; Department of Neurology, Baylor College of Medicine, Houston, TX, USA., Montaser-Kouhsari L; Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA., Desai N; Department of Neurology, Columbia University Medical Center, 650 W. 168th St, Rm 305, New York, NY, 10032, USA.; Initiative for Columbia Ataxia and Tremor, Columbia University Medical Center, New York, NY, USA., Pan MK; Department of Medical Research, National Taiwan University Hospital, 100, Taipei, Taiwan.; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, 100, Taipei, Taiwan.; Cerebellar Research Center, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan., Kuo SH; Department of Neurology, Columbia University Medical Center, 650 W. 168th St, Rm 305, New York, NY, 10032, USA. sk3295@cumc.columbia.edu.; Initiative for Columbia Ataxia and Tremor, Columbia University Medical Center, New York, NY, USA. sk3295@cumc.columbia.edu., Shohamy D; Department of Psychology, Columbia University, New York, NY, USA. ds2619@columbia.edu.; Zuckerman Mind Brain Behavior Institute, Columbia University, Quad 3D, 3227 Broadway, New York, NY, 10027, USA. ds2619@columbia.edu.; Kavli Institute for Brain Science, Columbia University, New York, NY, USA. ds2619@columbia.edu.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2024 Aug; Vol. 23 (4), pp. 1355-1368. Date of Electronic Publication: 2023 Dec 08.
DOI: 10.1007/s12311-023-01633-2
Abstrakt: Recent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with cerebellum dysfunction, represented by cerebellar ataxia cases. Nineteen participants with cerebellar ataxia and 57 age- and sex-matched healthy controls completed two separate tasks that required learning about reward contingencies from trial-and-error. To probe the selectivity of reward learning processes, the tasks differed in their underlying structure: while one task measured incremental reward learning ability alone, the other allowed participants to use an alternative learning strategy based on episodic memory alongside incremental reward learning. We found that individuals with cerebellar ataxia were profoundly impaired at reward learning from trial-and-error feedback on both tasks, but retained the ability to learn to predict reward based on episodic memory. These findings provide evidence from humans for a specific and necessary role for the cerebellum in incremental learning of reward associations based on reinforcement. More broadly, the findings suggest that alongside its role in motor learning, the cerebellum likely operates in concert with the basal ganglia to support reinforcement learning from reward.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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