Does base excess predict kidney injury in neonates with hypoxic-ischemic encephalopathy?

Autor: Kanmaz Kutman HG; Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey. Electronic address: gzdekanmaz@gmail.com., Kadıoğlu Şimşek G; Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey., Siyah Bilgin B; Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey., Akin MŞ; Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey., Canpolat FE; Department of Neonatology, University of Health Sciences, Ankara Bilkent City Hospital, Turkey.
Jazyk: angličtina
Zdroj: Early human development [Early Hum Dev] 2024 Jan; Vol. 188, pp. 105911. Date of Electronic Publication: 2023 Dec 06.
DOI: 10.1016/j.earlhumdev.2023.105911
Abstrakt: In neonates with hypoxic-ischemic encephalopathy (HIE), we studied the correlation between cord blood base excess (BE) and kidney function. Among 225 infants, 29 % had oliguria. BE levels differed significantly between oliguric and non-oliguric infants (p < 0.01), with a negative correlation to kidney injury (r = -0.544, p < 0.01). BE < -18 had 85 % specificity and 76 % sensitivity in predicting kidney injury (AUC = 0.88). These findings suggest BE as a valuable indicator of impending kidney injury in HIE infants, though underlying mechanisms may vary.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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