R3-Noria-methanesulfonate: A Molecular Cage with Superior Hyperpolarized Xenon-129 MRI Contrast.

Autor: Shepelytskyi Y; Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.; Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada., Grynko V; Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada.; Chemistry and Materials Science Program, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada., Batarchuk V; Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.; Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada., Hasselbrink CL; Department of Chemistry, University of Rhode Island, Kingston, Rhode Island 02881, United States., Kovacs AH; Applied Life Science Program, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada., Ruset IC; Xemed LCC, 16 Strafford Avenue, Durham, New Hampshire 03824, United States., Rodriguez K; Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada., Al Taradeh N; Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada., Talwar T; Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada., DeBoef B; Department of Chemistry, University of Rhode Island, Kingston, Rhode Island 02881, United States., Albert MS; Chemistry Department, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.; Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, Ontario P7B 6V4, Canada.; Northern Ontario School of Medicine, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Jazyk: angličtina
Zdroj: ACS sensors [ACS Sens] 2023 Dec 22; Vol. 8 (12), pp. 4707-4715. Date of Electronic Publication: 2023 Dec 08.
DOI: 10.1021/acssensors.3c01791
Abstrakt: Hyperpolarized (HP) xenon-129 ( 129 Xe) magnetic resonance imaging (MRI) has the potential to be used as a molecular imaging modality. For this purpose, numerous supramolecular cages have been developed and evaluated in the past. Herein, we report a novel and unique macrocycle that can be successfully utilized for xenon MRI, the resorcinarene trimer methanesulfonate (R3-Noria-MeSO 3 H). This molecule is capable of two different contrast mechanisms for xenon-MRI, resulting from an increase in the effective spin-spin relaxation and hyperpolarized chemical exchange saturation transfer (HyperCEST). We have demonstrated a superior negative contrast caused by R3-Noria-MeSO 3 H on HP 129 Xe MRI at 3.0 T as well as HyperCEST imaging of the studied macrocycle. Additionally, we have found that the complex aggregation behaviors of R3-Noria-methanesulfonate and its impact on xenon-129 relaxivity are an area for future study.
Databáze: MEDLINE
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