Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound.

Autor: Rice PA; FDA/CFSAN/OFAS/DFCN, 5001 Campus Drive, HFS 275, College Park, MD, 20740, USA. Electronic address: penelope.rice@fda.hhs.gov., Kabadi SV; FDA/CFSAN/OFAS/DFCN, 5001 Campus Drive, HFS 275, College Park, MD, 20740, USA., Doerge DR; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Vanlandingham MM; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Churchwell MI; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Tryndyak VP; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Fisher JW; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA., Aungst J; FDA/CFSAN/OFAS/DFCN, 5001 Campus Drive, HFS 275, College Park, MD, 20740, USA., Beland FA; FDA/NCTR, 3900 NCTR Road, Jefferson, AR, 72079, USA.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Jan; Vol. 183, pp. 114333. Date of Electronic Publication: 2023 Dec 05.
DOI: 10.1016/j.fct.2023.114333
Abstrakt: The 6:2 fluorotelomer alcohol (6:2 FTOH) is a common impurity in per- and polyfluoroalkyl substances (PFASs) used in many applications. Our previous toxicokinetic (TK) evaluation of 6:2 FTOH calculated times to steady state (tss) of one of its metabolites, 5:3 fluorotelomer carboxylic acid (5:3A), in the plasma and tissues of up to a year after oral exposure to rats. Our current work further elucidated the TK of 5:3A and other metabolites of 6:2 FTOH in pregnant and nonpregnant rats after repeated oral exposure and examined the role of renal transporters in the biopersistence of 5:3A. The tss values for 5:3A in serum and tissues of adult nonpregnant animals ranged from 150 days to over a year. 4:3 fluorotelomer carboxylic acid (4:3A) was an additional potentially-biopersistent metabolite. 5:3A was the major metabolite of 6:2 FTOH in serum of pregnant dams and fetuses at each time interval. 5:3A was not a substrate for renal transporters in a human kidney cell line in vitro, indicating that renal reuptake of 5:3A is unlikely contribute to its biopersistence. Further research is needed to identify the underlying processes and evaluate the impact of these 6:2 FTOH metabolites on human health.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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