Dissolution of spiral wave's core using cardiac optogenetics.

Autor: Hussaini S; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany., Lädke SL; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany., Schröder-Schetelig J; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany., Venkatesan V; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany., Quiñonez Uribe RA; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany., Richter C; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany.; WG Cardiovascular Optogenetics, Lab Animal Science Unit, Leibniz Institute for Primate research, Göttingen, Germany., Majumder R; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany., Luther S; Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Germany.; Institute for the Dynamics of Complex Systems, Göttingen University, Germany.
Jazyk: angličtina
Zdroj: PLoS computational biology [PLoS Comput Biol] 2023 Dec 07; Vol. 19 (12), pp. e1011660. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023).
DOI: 10.1371/journal.pcbi.1011660
Abstrakt: Rotating spiral waves in the heart are associated with life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation. These arrhythmias are treated by a process called defibrillation, which forces electrical resynchronization of the heart tissue by delivering a single global high-voltage shock directly to the heart. This method leads to immediate termination of spiral waves. However, this may not be the only mechanism underlying successful defibrillation, as certain scenarios have also been reported, where the arrhythmia terminated slowly, over a finite period of time. Here, we investigate the slow termination dynamics of an arrhythmia in optogenetically modified murine cardiac tissue both in silico and ex vivo during global illumination at low light intensities. Optical imaging of an intact mouse heart during a ventricular arrhythmia shows slow termination of the arrhythmia, which is due to action potential prolongation observed during the last rotation of the wave. Our numerical studies show that when the core of a spiral is illuminated, it begins to expand, pushing the spiral arm towards the inexcitable boundary of the domain, leading to termination of the spiral wave. We believe that these fundamental findings lead to a better understanding of arrhythmia dynamics during slow termination, which in turn has implications for the improvement and development of new cardiac defibrillation techniques.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Hussaini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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