CHOICES for sickle cell reproductive health: A protocol of a randomized preconception intervention model for a single gene disorder.

Autor: Wilkie DJ; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Telisnor G; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Powell-Roach K; College of Nursing, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America., Rangel AP; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Greenlee AL; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Ezenwa MO; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Gallo AM; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Black LV; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Gomes de Siqueira A; College of Engineering, University of Florida, Gainesville, Florida, United States of America., Dyal BW; College of Nursing, University of Florida, Gainesville, Florida, United States of America., Kalyanaraman S; College of Journalism and Communications, University of Florida, Gainesville, Florida, United States of America., Yao Y; College of Nursing, University of Florida, Gainesville, Florida, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Dec 07; Vol. 18 (12), pp. e0294907. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0294907
Abstrakt: Our long-term goal is to foster genetically informed reproductive health knowledge and behaviors among young adults with sickle cell disease (SCD) or sickle cell trait (SCT) with a web-based, tailored, multimedia intervention called CHOICES. CHOICES is designed to help young adults with SCD or SCT preconception to gain knowledge of genetic inheritance, specify their reproductive health intentions (their parenting plan), and engage in reproductive health behaviors concordant with their parenting plan. In a previous study, we found high acceptability of both the e-Book (usual care control) and CHOICES interventions. We also found sustained (24 months), significant effects on knowledge but not on behavior, most likely because half of the recruited group was not at risk for their children inheriting SCD. Hence, we propose an adequately powered randomized controlled trial with the CHOICES intervention and an e-Book control to compare their effects on genetic inheritance knowledge and at-risk reproductive health behaviors (immediate posttest and at 6, 12, 18, and 24 months). We will conduct subgroup analyses to provide insight into the baseline knowledge and behavior as well as the intervention effects in different demographic or acceptability groups. Given the scalability and low cost of CHOICES, if proved to be effective, it can reach the affected population at low cost.
Competing Interests: D.J.W. is chairman and founder of eNursing llc, a company with no interests in the work presented in this manuscript. All other authors declare no conflicts of interests.
(Copyright: © 2023 Wilkie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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