Multivariate and regional age-related change in basal ganglia iron in neonates.

Autor:	Cabral L; Department of Radiology University of Pittsburgh, Pittsburgh, PA 15224, United States., Calabro FJ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States.; Department of Bioengineering, University of Pittsburgh, 15213, United States., Foran W; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States., Parr AC; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States., Ojha A; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, United States.; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15213, United States., Rasmussen J; Development, Health and Disease Research Program, University of California, Irvine, CA 92697, United States.; Department of Pediatrics, University of California, Irvine, CA 92697, United States., Ceschin R; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15224, United States., Panigrahy A; Department of Radiology University of Pittsburgh, Pittsburgh, PA 15224, United States., Luna B; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, United States.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Jan 14; Vol. 34 (1).
DOI:	10.1093/cercor/bhad456
Abstrakt:	In the perinatal period, reward and cognitive systems begin trajectories, influencing later psychiatric risk. The basal ganglia is important for reward and cognitive processing but early development has not been fully characterized. To assess age-related development, we used a measure of basal ganglia physiology, specifically brain tissue iron, obtained from nT2* signal in resting-state functional magnetic resonance imaging (rsfMRI), associated with dopaminergic processing. We used data from the Developing Human Connectome Project (n = 464) to assess how moving from the prenatal to the postnatal environment affects rsfMRI nT2*, modeling gestational and postnatal age separately for basal ganglia subregions in linear models. We did not find associations with tissue iron and gestational age [range: 24.29-42.29] but found positive associations with postnatal age [range:0-17.14] in the pallidum and putamen, but not the caudate. We tested if there was an interaction between preterm birth and postnatal age, finding early preterm infants (GA < 35 wk) had higher iron levels and changed less over time. To assess multivariate change, we used support vector regression to predict age from voxel-wise-nT2* maps. We could predict postnatal but not gestational age when maps were residualized for the other age term. This provides evidence subregions differentially change with postnatal experience and preterm birth may disrupt trajectories. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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