Altering maternal calcium and phosphorus dietary intake induces persistent sex-specific changes in the dentition of the offspring.

Autor: Hassan MG; Department of Orthodontics, Faculty of Dentistry, Assiut University, Assiut, Egypt.; Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA., Hassan R; Department of Endodontics, Faculty of Dentistry, Minia University, Minia, Egypt.; Department of Endodontics, Faculty of Dentistry, The Egyptian Russian University, Badr City, Egypt., Hassan DG; Department of Environmental Medical Sciences, Faculty of Graduate Studies and Environmental Research, Ain Shams University, Cairo, Egypt., Abdelrahman HH; Department of Pediatric Dentistry, and Dental Public Health, Faculty of Dentistry, Alexandria, University, Alexandria, Egypt., Cox TC; Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, Washington, USA., Jheon AH; Divisions of Craniofacial Anomalies and Orthodontics, UCSF, San Francisco, California, USA.
Jazyk: angličtina
Zdroj: Orthodontics & craniofacial research [Orthod Craniofac Res] 2024 Jun; Vol. 27 (3), pp. 403-412. Date of Electronic Publication: 2023 Dec 07.
DOI: 10.1111/ocr.12742
Abstrakt: Background: The maternal diet is essential to offspring development, but the specific effects on tooth morphology are still unknown. The aim of this study was to evaluate the effects of altering maternal calcium (Ca) and phosphorus (P) supplementation during gestation and lactation on offspring dentition.
Methods: Pregnant mice were fed an experimental diet containing a threefold increase in Ca and a threefold decrease in P compared to the standard mouse chow diet at embryonic Day 0.5 (E0.5). Offspring mice were maintained on standard or experimental diets from post-natal Day 0 to weaning, then fed control diets until 6 weeks of age. Six-week-old offspring heads were collected and scanned using micro-computed tomography. Dental morphometrics of offspring maxillary and mandibular first and third molars (n = 5-6 per diet/per sex) were determined. A two-way ANOVA test was employed to verify the existence of any significant differences between groups. The significance level was set at P < .05.
Results: A two-way ANOVA revealed a statistically significant interaction between the effects of diet and sex on the upper and lower dentition. Moreover, experimental diet-fed female offspring exhibited smaller molars with shorter mesiodistal width and larger pulp chambers relative to controls, while experimental diet-fed male offspring possessed larger molars with wider mesiodistal width and smaller pulp chambers.
Conclusion: Our findings reveal that altering the maternal and offspring dietary Ca:P ratio during gestation, lactation and weaning led to significant, sex-specific changes in the offspring dentition. The differences in dentition appeared to be correlated with the sex-specific changes in the craniofacial skeleton.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: