HPV-negative head and neck cancers with adverse pathological features carry specific molecular changes that are associated with survival.

Autor:	Kim HAJ; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada., Zeng PYF; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada., Cecchini M; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada., Shaikh MH; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada., Laxague F; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada., Deng X; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada., Jarycki L; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada., Ryan SEB; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada., Dawson A; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.; Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada., Liu MH; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada., Palma DA; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.; Department of Oncology, University of Western Ontario, London, Ontario, Canada., Patel K; Department of Otolaryngology-Head & Neck Surgery, Moffitt Cancer Center, Tampa, Florida, USA., Mundi N; Department of Otolaryngology-Head & Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA., Barrett JW; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.; Department of Oncology, University of Western Ontario, London, Ontario, Canada., Mymryk JS; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.; Department of Oncology, University of Western Ontario, London, Ontario, Canada.; Department of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada., Boutros PC; Department of Human Genetics, University of California, Los Angeles, California, USA.; Department of Urology, University of California, Los Angeles, California, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California, USA.; Institute for Precision Health, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, California, USA., Nichols AC; Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.; Department of Oncology, University of Western Ontario, London, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Head & neck [Head Neck] 2024 Feb; Vol. 46 (2), pp. 353-366. Date of Electronic Publication: 2023 Dec 07.
DOI:	10.1002/hed.27591
Abstrakt:	Background: Adverse pathological features following surgery in head and neck squamous cell carcinoma (HNSCC) are strongly associated with survival and guide adjuvant therapy. We investigated molecular changes associated with these features. Methods: We downloaded data from the Cancer Genome Atlas and Cancer Proteome Atlas HNSCC cohorts. We compared tumors positive versus negative for perineural invasion (PNI), lymphovascular invasion (LVI), extracapsular spread (ECS), and positive margins (PSM), with multivariable analysis. Results: All pathological features were associated with poor survival, as were the following molecular changes: low cyclin E1 (HR = 1.7) and high PKC-alpha (HR = 1.8) in tumors with PNI; six of 13 protein abundance changes with LVI; greater tumor hypoxia and high Raptor (HR = 2.0) and Rictor (HR = 1.6) with ECS; and low p38 (HR = 2.3), high fibronectin (HR = 1.6), low annexin A1 (HR = 3.1), and high caspase-9 (HR = 1.6) abundances with PSM. Conclusions: Pathological features in HNSCC carry specific molecular changes that may explain their poor prognostic associations. (© 2023 Wiley Periodicals LLC.)
Databáze:	MEDLINE
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