Partial or Complete Loss of Norepinephrine Differentially Alters Contextual Fear and Catecholamine Release Dynamics in Hippocampal CA1.
| Autor: | Wilson LR; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.; Neurobehavioral Core Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Plummer NW; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Evsyukova IY; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Patino D; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Stewart CL; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Smith KG; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Konrad KS; Social and Scientific Systems, Inc., a DLH Holdings Corp Company, Durham, North Carolina., Fry SA; Neurobehavioral Core Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Deal AL; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Kilonzo VW; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Panda S; Neurobehavioral Core Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Sciolino NR; Department of Physiology and Neurobiology, Department of Biomedical Engineering, Institute for System Genomics, Connecticut Institute for the Brain & Cognitive Sciences, University of Connecticut, Storrs, Connecticut., Cushman JD; Neurobehavioral Core Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina., Jensen P; Neurobiology Laboratory, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2023 Oct 12; Vol. 4 (1), pp. 51-60. Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2024). |
| DOI: | 10.1016/j.bpsgos.2023.10.001 |
| Abstrakt: | Background: Contextual fear learning is heavily dependent on the hippocampus. Despite evidence that catecholamines contribute to contextual encoding and memory retrieval, the precise temporal dynamics of their release in the hippocampus during behavior is unknown. In addition, new animal models are required to probe the effects of altered catecholamine synthesis on release dynamics and contextual learning. Methods: We generated 2 new mouse models of altered locus coeruleus-norepinephrine (NE) synthesis and utilized them together with GRAB Results: Aversive foot shock increased both NE and DA release in the dorsal CA1, while freezing behavior associated with recall of fear memory was accompanied by decreased release. Moreover, we found that freezing at the recent time point was sensitive to both partial and complete loss of locus coeruleus-NE synthesis throughout prenatal and postnatal development, similar to previous observations of mice with global loss of NE synthesis beginning postnatally. In contrast, freezing at the remote time point was compromised only by complete loss of locus coeruleus-NE synthesis beginning prenatally. Conclusions: Overall, these findings provide novel insights into the role of NE in contextual fear and the precise temporal dynamics of both NE and DA during freezing behavior and highlight complex relationships between genotype, sex, and NE signaling. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|