Relative Effects of Minoxidil 5%, Platelet-Rich Plasma, and Microneedling in Pattern Hair Loss: A Systematic Review and Network Meta-Analysis.
| Autor: | Gupta AK; Mediprobe Research Inc., London, ON, Canada.; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada., Wang T; Mediprobe Research Inc., London, ON, Canada., Bamimore MA; Mediprobe Research Inc., London, ON, Canada., Polla Ravi S; Mediprobe Research Inc., London, ON, Canada., Talukder M; Mediprobe Research Inc., London, ON, Canada.; School of Pharmacy, BRAC University, Dhaka, Bangladesh. |
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| Jazyk: | angličtina |
| Zdroj: | Skin appendage disorders [Skin Appendage Disord] 2023 Dec; Vol. 9 (6), pp. 397-406. Date of Electronic Publication: 2023 Oct 27. |
| DOI: | 10.1159/000534196 |
| Abstrakt: | Background: Combination treatments may improve the utility of approved agents for the treatment of pattern hair loss (PHL); however, head-to-head comparisons are lacking. Objective: The aim of the study was to compare the efficacy of 5% minoxidil, platelet-rich plasma (PRP), and microneedling across adults with PHL insofar as change in total hair density at 24 weeks. Methods: We conducted a literature search in July 2022. Through our Bayesian network meta-analysis, we estimated treatments' surface under the cumulative ranking distribution (SUCRA) values and relative effects - in terms of mean difference (MD). Results: Data from 27 trials, totaling 1,110 patients, were extracted. Interventions were ranked based on the probability of inducing hair density improvements: 5% minoxidil plus microneedling (SUCRA = 95.8%), 5% minoxidil plus PRP (SUCRA = 64.7%), 5% minoxidil (SUCRA = 53.9%), PRP (SUCRA = 34.9%), microneedling (SUCRA = 27.8%), and PRP with microneedling (SUCRA = 22.9%). The efficacy of 5% minoxidil plus microneedling in improving total hair density was significantly greater ( p < 0.05) than 5% minoxidil monotherapy (MD = 13 hairs/cm 2 ), PRP monotherapy (MD = 16 hairs/cm 2 ), and microneedling monotherapy (MD = 17 hairs/cm 2 ). Conclusion: Five percent minoxidil plus microneedling is an effective treatment option for improving hair density at 6 months in adult PHL patients. Competing Interests: The authors have no conflict of interest to declare. (© 2023 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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