Hematopoietic cell transplantation and cellular therapies in Switzerland. Evolution over 25 years. A report from the stem cell transplantation and cellular therapies working groups of the SBST 1997-2021.

Autor: Passweg JR; Hematology Division and Pediatric Hematology-oncology University Hospital and Children's University Hospital, Basel, Switzerland., Baldomero H; SBST Data Registry Office, University Hospital, Basel, Switzerland., Ansari M; Division of Hematology, Division of Pediatric Oncology and Hematology, University Hospital Geneva (HUG), Cansearch Research Platform for Pediatric Oncology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Arber C; Service and Central Laboratory of Hematology, Service of Immunooncology, Departments of Oncology, Laboratory Medicine and Pathology, University Hospital, Lausanne, Switzerland., Chalandon Y; Division of Hematology, Division of Pediatric Oncology and Hematology, University Hospital Geneva (HUG), Cansearch Research Platform for Pediatric Oncology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Daskalakis M; Department of Medical Oncology, Department of Hematology and Central Hematology Laboratory, Division of Hematology/Oncology Department of Pediatrics University Hospital Inselspital and University of Berne, Bern, Switzerland., Diepold M; Department of Medical Oncology, Department of Hematology and Central Hematology Laboratory, Division of Hematology/Oncology Department of Pediatrics University Hospital Inselspital and University of Berne, Bern, Switzerland., Diesch-Furlanetto T; Hematology Division and Pediatric Hematology-oncology University Hospital and Children's University Hospital, Basel, Switzerland., Duchosal MA; Service and Central Laboratory of Hematology, Service of Immunooncology, Departments of Oncology, Laboratory Medicine and Pathology, University Hospital, Lausanne, Switzerland., Gerull S; Division of Hematology/Oncology, Kantonsspital, Gt. Gallen, Switzerland., Güngör T; Department of Immunology/Hematology/Oncology/Stem Cell Transplantation and Gene-Therapy, University Children's Hospital, Zurich, Switzerland., Heim D; Hematology Division and Pediatric Hematology-oncology University Hospital and Children's University Hospital, Basel, Switzerland., Hitz F; Division of Medical Oncology and Hematology, Kantonsspital, St. Gallen, Switzerland., Holbro A; Hematology Division and Pediatric Hematology-oncology University Hospital and Children's University Hospital, Basel, Switzerland., Masouridi-Levrat S; Division of Hematology, Division of Pediatric Oncology and Hematology, University Hospital Geneva (HUG), Cansearch Research Platform for Pediatric Oncology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Nair G; Swiss Blood Stem Cells, Donor Registry, Swiss Transfusion SRC, Berne, Switzerland., Novak U; Department of Medical Oncology, Department of Hematology and Central Hematology Laboratory, Division of Hematology/Oncology Department of Pediatrics University Hospital Inselspital and University of Berne, Bern, Switzerland., Pabst T; Department of Medical Oncology, Department of Hematology and Central Hematology Laboratory, Division of Hematology/Oncology Department of Pediatrics University Hospital Inselspital and University of Berne, Bern, Switzerland., Renner C; Division of Hematology/Oncology, Clinic Hirslanden, Zurich, Switzerland., Stussi G; Division of Hematology, Istituto Oncologico Della Svizzera Italiana, Ospedale San Giovanni, Bellinzona, Switzerland., Schneidawind D; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Schanz U; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Wannesson L; Division of Hematology, Istituto Oncologico Della Svizzera Italiana, Ospedale San Giovanni, Bellinzona, Switzerland., Halter JP; Hematology Division and Pediatric Hematology-oncology University Hospital and Children's University Hospital, Basel, Switzerland.
Jazyk: angličtina
Zdroj: Hematological oncology [Hematol Oncol] 2024 Jan; Vol. 42 (1), pp. e3241. Date of Electronic Publication: 2023 Dec 06.
DOI: 10.1002/hon.3241
Abstrakt: The Swiss Blood Stem Cell Transplantation and Cellular Therapy Group (SBST) leads a mandatory national registry for all hematopoietic stem cell transplants (HCT) and cellular therapies. After 25 years, information was available for 11,226 patients receiving an HCT (4031 allogeneic and 7195 autologous), including 925 pediatric patients. We compared patient characteristics and outcome by quinquennia 1997-2001, 2002-2006, 2007-2011, 2012-2016, and 2017-2021. There were numerous changes over time. Allogeneic transplant recipients became older (median age 33.7 vs. 54.3) and had more frequently unrelated donors and reduced intensity conditioning in later quinquennia. Similarly, age increased for recipients of autologous HCT (median 48.3 vs. 59.9). We did not see a significant drop in transplant activity during the SARS-CoV-2 pandemic. Analysis of outcome showed overall survival (relative risk (RR) of death 0.664 (0.529-0.832) and progression free survival (RR 0.708 (0.577-0.870) being improved over time comparing the latest to the first quinquennium adjusting for risk factors. Non-relapse mortality decreased in recipients of allogeneic HCT (RR: 0.371 (0.270-0.509)) over time but relapse risks did not. Outcome of autologous HCT improved as well across quinquennia, this improvement was mainly due to decreased relapse risks (RR 0.681 (0.597-0.777)), possibly related to maintenance treatment or rescue treatment for relapse mainly in myeloma patients. Cellular therapies other than allogeneic or autologous HCT, particularly chimeric antigen receptor T-cells (CAR-T) treatment have started to increase after 2019, year of approval of the first commercial CAR-T product in Switzerland. Data on chimeric antigen receptor T-cell treatment are too early for comparative analyses. Detailed analyses of changes over time are presented. This study includes all HCTs, and cellular therapies, data useful for quality assurance programs, health care cost estimation and benchmarking. Between 50% and 60% of patients are long-term survivors after both types of HCT, indicating growing populations of surviving patients requiring long-term care.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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