Anthelmintic and Hepatoprotective Activities of the Green-Synthesized Zinc Oxide Nanoparticles Against Parascaris equorum Infection in Rats.

Autor: Ali SB; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt. sbayoumy@cu.edu.eg., Mohamed AS; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt., Fahmy SR; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt., El-Garhy M; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt., Mousa MR; Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Abdel-Ghaffar F; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Jazyk: angličtina
Zdroj: Acta parasitologica [Acta Parasitol] 2024 Mar; Vol. 69 (1), pp. 283-301. Date of Electronic Publication: 2023 Dec 06.
DOI: 10.1007/s11686-023-00728-4
Abstrakt: Main Conclusions: Green-synthesized zinc oxide nanoparticle is a promising treatment modality against parasitic infection through its powerful anthelmintic, antioxidant, healing promotion, and anti-inflammation effects.
Background: Nanoparticles have many properties, depending on their size, shape, and morphology, allowing them to interact with microorganisms, plants, and animals.
Objectives: Investigation of the therapeutic effects of green-synthesized zinc oxide nanoparticles (ZnO NPs) on Parascaris equorum infection in rats.
Methods: Thirty-six rats were divided into two divisions: the first division is noninfected groups were allocated into three groups. Group 1: Control, group 2: ZnO NPs (30 mg/kg), and group 3: ZnO NPs (60 mg/kg). The second division is infected groups were allocated into three groups. Group 1: vehicle, group 2: ZnO NPs (30 mg/kg), and group 3: ZnO NPs (60 mg/kg).
Findings: Ten days post-infection, two larvae per gram of liver tissue were present in the vehicle group compared to the control group. No larvae were recovered from ZnO NPs (30 mg/kg), and one larva/g.tissue from ZnO NPs (60 mg/kg)-treated groups compared to untreated infected animals. Green-synthesized ZnO NPs caused a significant decrease in liver functions, low-density lipoprotein (LDL), cholesterol, triglycerides, malondialdehyde (MDA), and nitric oxide (NO). While it caused a significant increase in hemoglobin (HB), high-density lipoprotein (HDL), butyrylcholinesterase (BCHE), glutathione (GSH), catalase (CAT), and glutathione S-transferase (GST) in infected treated rats. The histological inflammation and fibroplasia scores showed a significant enhancement during the treatment with ZnO NPs (30, 60 mg/kg) compared to the infected untreated animals that scored the highest pathological destruction score. Immunohistochemical markers of NF-κB showed a significant decrease during the treatment with ZnO NPs (30, 60 mg/kg) compared to the infected untreated animals.
(© 2023. The Author(s).)
Databáze: MEDLINE
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