Serum uric acid predicts the development of atherosclerosis in women but not in men: A ten-year cohort study in China.

Autor: Li L; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China., Tian X; Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, China., Gao Y; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China., Gu Y; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China., Zhang K; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China., Li L; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China., Wang H; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Cerebral Network and Cognitive Disorders, Shijiazhuang, Hebei, China. Electronic address: wanghbhope@hebmu.edu.cn., He W; Department of Neurology, Heyuan People's Hospital, Guangdong Provincial People's Hospital Heyuan Hospital, Heyuan, China; Heyuan Key Laboratory of Molecular Diagnosis & Disease Prevention and Treatment, Doctors Station of Guangdong Province, Heyuan People's Hospital, Heyuan, Guangdong, 517000, China. Electronic address: hwl19851007@126.com.
Jazyk: angličtina
Zdroj: Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2024 Jan; Vol. 34 (1), pp. 198-205. Date of Electronic Publication: 2023 Oct 12.
DOI: 10.1016/j.numecd.2023.10.005
Abstrakt: Background and Aim: Atherosclerosis is becoming a significant health burden. Serum uric acid (SUA) is the final enzymatic product of purine metabolism and can contribute to the development of atherosclerosis. The aim of this study was to explore the possible predictive value of SUA in the development of atherosclerosis in a healthy Chinese population.
Methods and Results: In this study, a total of 11,222 healthy subjects with no carotid plaque at baseline were enrolled and divided into sex-specific groups, and then the occurrence of carotid plaque during the follow-up time was documented. The association between carotid plaque and SUA levels was examined using Cox proportional-hazards regression models. The mean SUA level was 5.35 ± 1.41 mg/dL. A total of 2,911 individuals (25.94%) developed carotid plaque during the follow-up time, including 1,071 females and 1,840 males. After adjusting for potential confounding factors, the hazard ratio (HR) and 95% confidence interval (95% CI) in women for the occurrence of carotid plaque associated with SUA levels were 1.163 (1.017-1.330), but no significant correlation was found in men, as the HR was 1.050 (0.965-1.143).
Conclusion: Our results indicate that SUA levels predict the development of carotid plaque independent of traditional risk factors only in women.
Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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