Relation of the kynurenine pathway with normal age: A systematic review.

Autor:	Bakker L; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands; Alzheimer Center Limburg, Maastricht University, 6229 ET Maastricht, the Netherlands., Choe K; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands., Eussen SJPM; Department of Epidemiology, Maastricht University, 6229 HA Maastricht, the Netherlands; School for Cardiovascular Diseases (CARIM) and Care and Public Health Research Institute (CAPHRI), 6229 ER Maastricht, the Netherlands., Ramakers IHGB; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands; Alzheimer Center Limburg, Maastricht University, 6229 ET Maastricht, the Netherlands., van den Hove DLA; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, 97080 Wuerzburg, Germany., Kenis G; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands., Rutten BPF; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands; Alzheimer Center Limburg, Maastricht University, 6229 ET Maastricht, the Netherlands., Verhey FRJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands; Alzheimer Center Limburg, Maastricht University, 6229 ET Maastricht, the Netherlands., Köhler S; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs) and European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Sciences (FHML) Maastricht University, 6229 ER Maastricht, the Netherlands; Alzheimer Center Limburg, Maastricht University, 6229 ET Maastricht, the Netherlands. Electronic address: s.koehler@maastrichtuniversity.nl.
Jazyk:	angličtina
Zdroj:	Mechanisms of ageing and development [Mech Ageing Dev] 2024 Feb; Vol. 217, pp. 111890. Date of Electronic Publication: 2023 Dec 05.
DOI:	10.1016/j.mad.2023.111890
Abstrakt:	Background: The kynurenine pathway (KP) is gaining more attention as a common pathway involved in age-related conditions. However, which changes in the KP occur due to normal ageing is still largely unclear. The aim of this systematic review was to summarize the available evidence for associations of KP metabolites with age. Methods: We used an broad search strategy and included studies up to October 2023. Results: Out of 8795 hits, 55 studies were eligible for the systematic review. These studies suggest that blood levels of tryptophan decrease with age, while blood and cerebrospinal fluid levels of kynurenine and its ratio with tryptophan increase. Studies investigating associations between cerebrospinal fluid and blood levels of kynurenic acid and quinolinic acid with age reported either positive or non-significant findings. However, there is a large heterogeneity across studies. Additionally, most studies were cross-sectional, and only few studies investigated associations with other downstream kynurenines. Conclusions: This systematic review suggests that levels of kynurenines are positively associated with age. Larger and prospective studies are needed that also investigate a more comprehensive panel of KP metabolites and changes during the life-course. Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests. (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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