Inbreeding depression for producer-recorded udder, metabolic, and reproductive diseases in US dairy cattle.

Autor:	Lozada-Soto EA; Department of Animal Science, North Carolina State University, Raleigh, NC 27607. Electronic address: emmanuel.lozadasoto@usda.gov., Parker Gaddis KL; Council on Dairy Cattle Breeding, Bowie, MD 20716., Tiezzi F; Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, 50144 Florence, Italy., Jiang J; Department of Animal Science, North Carolina State University, Raleigh, NC 27607., Ma L; Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742., Toghiani S; Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Service, USDA, Beltsville, MD 20705., VanRaden PM; Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Service, USDA, Beltsville, MD 20705., Maltecca C; Department of Animal Science, North Carolina State University, Raleigh, NC 27607.
Jazyk:	angličtina
Zdroj:	Journal of dairy science [J Dairy Sci] 2024 May; Vol. 107 (5), pp. 3032-3046. Date of Electronic Publication: 2023 Dec 04.
DOI:	10.3168/jds.2023-23909
Abstrakt:	This study leveraged a growing dataset of producer-recorded phenotypes for mastitis, reproductive diseases (metritis and retained placenta), and metabolic diseases (ketosis, milk fever, and displaced abomasum) to investigate the potential presence of inbreeding depression for these disease traits. Phenotypic, pedigree, and genomic information were obtained for 354,043 and 68,292 US Holstein and Jersey cows, respectively. Total inbreeding coefficients were calculated using both pedigree and genomic information; the latter included inbreeding estimates obtained using a genomic relationship matrix and runs of homozygosity. We also generated inbreeding coefficients based on the generational inbreeding for recent and old pedigree inbreeding, for different run-of-homozygosity length classes, and for recent and old homozygous-by-descent segment-based inbreeding. Estimates on the liability scale revealed significant evidence of inbreeding depression for reproductive-disease traits, with an increase in total pedigree and genomic inbreeding showing a notable effect for recent inbreeding. However, we found inconsistent evidence for inbreeding depression for mastitis or any metabolic diseases. Notably, in Holsteins, the probability of developing displaced abomasum decreased with inbreeding, particularly for older inbreeding. Estimates of disease probability for cows with low, average, and high inbreeding levels did not significantly differ across any inbreeding coefficient and trait combination, indicating that although inbreeding may affect disease incidence, it likely plays a smaller role compared with management and environmental factors. (The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)
Databáze:	MEDLINE
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