Clinical outcomes and mortality in patients with atrial fibrillation and recently diagnosed lung cancer in oncology outpatient settings.

Autor: Piserra López-Fernández De Heredia A; Department of Cardiology, Reina Sofia University Hospital, Cordoba, Spain., Ruiz Ortiz M; Department of Cardiology, Reina Sofia University Hospital, Cordoba, Spain; Maimonides Institute for Biomedical Research of Cordoba, IMIBIC, Cordoba, Spain. Electronic address: maruor@gmail.com., Pérez Cabeza AI; Cardiology Department. CIBERCV. Virgen de la Victoria University Hospital, Málaga, Spain., Díaz Expósito A; Department of Cardiology, Virgen de la Victoria University Hospital, Málaga, Spain., Fernández Valenzuela MI; Department of Cardiology, Virgen de la Macarena University Hospital, Sevilla, Spain., Carrillo Bailén M; Department of Cardiology, Jaén University Hospital, Jaén, Spain., Alarcón De La Lastra Cubiles I; Department of Cardiology, Puerta del Mar University Hospital, Cádiz, Spain., Moreno Vega A; Department of Medical Oncology, Reina Sofia University Hospital, Cordoba, Spain., Zalabardo Aguilar M; Department of Medical Oncology, Virgen de la Victoria University Hospital, Málaga, Spain., Chaparro Muñoz M; Department of Cardiology, Virgen de la Macarena University Hospital, Sevilla, Spain., García Manrique T; Department Medical Oncology, Virgen de la Macarena University Hospital, Sevilla, Spain., Torres Llergo J; Department of Cardiology, Jaén University Hospital, Jaén, Spain., Ortega Granados AL; Department of Medical Oncology, Jaén University Hospital, Jaén, Spain., Sánchez Fernández JJ; Department of Cardiology, Puerta del Mar University Hospital, Cádiz, Spain., Calvete Cadenas J; Department of Medical Oncology, Puerta del Mar University Hospital, Cádiz, Spain., Mesa Rubio D; Department of Cardiology, Reina Sofia University Hospital, Cordoba, Spain; Maimonides Institute for Biomedical Research of Cordoba, IMIBIC, Cordoba, Spain.
Jazyk: angličtina
Zdroj: Current problems in cardiology [Curr Probl Cardiol] 2024 Feb; Vol. 49 (2), pp. 102239. Date of Electronic Publication: 2023 Dec 05.
DOI: 10.1016/j.cpcardiol.2023.102239
Abstrakt: Introduction: Our aim was to investigate the prevalence of atrial fibrillation (AF) and recently diagnosed lung cancer in the outpatient oncology clinic and to describe the clinical profile, management and outcomes of this population.
Methods: Among 6984 patients visited at the outpatient oncology clinics attending lung cancer patients in five university hospitals from 2017 to 2019, all consecutive subjects with recently diagnosed (<1 year) disease and AF were retrospectively selected and events in follow up were registered.
Results: A total of 269 patients (3.9 % of all attended, 71 ± 8 years, 91 % male) were included. Charlson, CHA2DS2-VASc and HAS-BLED indexes were 6.7 ± 2.9, 2.9 ± 1.5 y 2.5 ± 1.2, respectively. Tumour stage was I, II, III and IV in 11 %, 11 %, 33 % and 45 % of them, respectively. Anticoagulants were prescribed to 226 patients (84 %): direct anticoagulants (n = 99;44 %), low molecular weight heparins (n = 69;30 %) and vitamin K antagonists (n = 58;26 %). After 46 months of maximum follow-up, 186 patients died (69 %). Cumulative incidences of events at 3 years were 3.3 ± 1.3 % for stroke/systemic embolism (n = 7); 8.9 ± 2.2 % for thrombotic events (n = 18); 9.9 ± 2.6 % for major bleeding (n = 16), and 15.9 ± 3,0 % for cardiovascular events (n = 33). In patients with early stages of cancer (I-II), 2-year mortality was significantly higher in those with cardiovascular events or major bleeding (85 % vs 25 %, p = 0.01).
Conclusion: Nearly 4 % or all outpatients in the oncology clinic attending lung cancer present recently diagnosed disease and AF. Major bleeding and cardiovascular event rates are high in this population, with an impact on mortality in early stages of cancer.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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